-α-醛亚胺硫酯的烷基化/羟醛反应：一种简便的三组分偶联反应。
-Alkylation/aldol reaction of α-aldimino thioesters: a facile three-component coupling reaction.
作者信息
Shimizu Makoto, Higashino Asako, Mizota Isao, Zhu Yusong
机构信息
School of Energy Science and Engineering, Nanjing Tech University Nanjing 211816 Jiangsu Province China.
Department of Chemistry for Materials, Graduate School of Engineering, Mie University Tsu Mie 514-8507 Japan
出版信息
RSC Adv. 2021 Apr 7;11(22):13097-13104. doi: 10.1039/d1ra02000e.
Abstract
Theoretical calculation of the reactivity of α-imino thioesters indicates that they are very reactive substrates for Umpolung -alkylation. In fact, treatment of α-aldimino thioesters with dialkylzinc reagents in the presence of aldehydes or imines gives three-component coupling products in good yields.
摘要
α-亚氨基硫酯反应活性的理论计算表明，它们是极性翻转烷基化反应中非常活泼的底物。事实上，在醛或亚胺存在的情况下，用二烷基锌试剂处理α-醛亚氨基硫酯能以良好的产率得到三组分偶联产物。
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