肉桂酸和苯丙素衍生物的抗氧化和促氧化潜力在调节培养细胞生长中的作用。
Roles of anti- and pro-oxidant potential of cinnamic acid and phenylpropanoid derivatives in modulating growth of cultured cells.
作者信息
Lee Bo-Hyun, Choi Hyeon-Son, Hong Jungil
机构信息
Division of Applied Food System, College of Natural Science, Seoul Women's University, 621 Hwarangno, Nowon-gu, Seoul, 01797 Korea.
Department of Pharmacology, Physiology and Neuroscience, Rutgers, New Jersey Medical School, Newark, NJ 07103 USA.
出版信息
Food Sci Biotechnol. 2022 Feb 28;31(4):463-473. doi: 10.1007/s10068-022-01042-x. eCollection 2022 Apr.
UNLABELLED
Cinnamic acid (CiA) and phenylpropanoid derivatives are widely distributed in plant foods. In this study, anti- and pro-oxidant properties of the derivatives and their roles in modulating cell growth were investigated. Ferulic acid, sinapinic acid, caffeic acid (CaA), and 3,4-dihydroxyhydrocinnamic acid (DHC) showed strong radical scavenging activities. They, except DHC, also performed considerable inhibitory effects on lipid peroxidation and reduced levels of intracellular reactive oxygen species (ROS). CaA and DHC, however, produced substantial amount of HO with oxidative degradation in culture conditions. CaA and DHC (> 400 μM) showed potent cytotoxic effects which were abolished by superoxide dismutase/catalase; they significantly enhanced cell growth ROS-dependently at low levels (~ 100 μM). CiA derivatives without bearing hydroxyl group did not show any appreciable antioxidant activities. The results indicate that CiA derivatives with -dihydroxyl group had strong anti- and pro-oxidant properties, which also play an important role in modulating cell growth.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s10068-022-01042-x.
未标记
肉桂酸（CiA）和苯丙素衍生物广泛分布于植物性食物中。在本研究中，对这些衍生物的抗氧化和促氧化特性及其在调节细胞生长中的作用进行了研究。阿魏酸、芥子酸、咖啡酸（CaA）和3,4-二羟基氢化肉桂酸（DHC）表现出较强的自由基清除活性。除DHC外，它们对脂质过氧化也有相当的抑制作用，并降低了细胞内活性氧（ROS）水平。然而，CaA和DHC在培养条件下通过氧化降解产生了大量的羟基自由基（HO）。CaA和DHC（>400μM）表现出强大的细胞毒性作用，超氧化物歧化酶/过氧化氢酶可消除这种作用；在低水平（~100μM）时，它们以ROS依赖性方式显著促进细胞生长。不含羟基的CiA衍生物未表现出任何明显的抗氧化活性。结果表明，具有二羟基的CiA衍生物具有强大的抗氧化和促氧化特性，这在调节细胞生长中也起着重要作用。
补充信息
在线版本包含可在10.1007/s10068-022-01042-x获取的补充材料。
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