Department of Pulmonary Medicine and Tuberculosis, The Third People's Hospital of Shenzhen, China, The National Clinical Research Center for Infectious Diseases, Shenzhen, China.
Drug Discov Ther. 2022 May 17;16(2):52-54. doi: 10.5582/ddt.2022.01029. Epub 2022 Apr 23.
Individuals in close contact with multidrug-resistant tuberculosis (MDR-TB) patients are subject to an elevated risk of infection, and may develop latent MDR-TB infection. Numerous studies have described latent tuberculosis infection (LTBI) as a reservoir of new TB disease. The screening and treatment of latent MDR-TB infection are challenging. Hereby, we reviewed the epidemiology, current management and prevention approach of LTBI in MDR-TB close contacts, to provide additional information for future research direction and policy design formulation to reduce the LTBI reservoir.
与耐多药结核病（MDR-TB）患者密切接触的个体感染风险增加，可能会发展为潜伏性 MDR-TB 感染。许多研究将潜伏性结核感染（LTBI）描述为新结核病发病的蓄水池。潜伏性 MDR-TB 感染的筛查和治疗具有挑战性。因此，我们综述了 MDR-TB 密切接触者中 LTBI 的流行病学、当前管理和预防方法，为未来的研究方向和政策设计制定提供了更多信息，以减少 LTBI 蓄水池。
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