甲硝唑、替硝唑和奥硝唑治疗肠道溶组织内阿米巴和蓝氏贾第鞭毛虫的比较研究

Treatment of intestinal E. histolytica and G. lamblia with metronidazole, tinidazole and ornidazole: a comparative study.

作者信息

Bassily S, Farid Z, el-Masry N A, Mikhail E M

出版信息

J Trop Med Hyg. 1987 Feb;90(1):9-12.

Abstract

Metronidazole, tinidazole and ornidazole were compared in patients treated for Entamoeba histolytica or Giardia lamblia intestinal infections. Only patients with three positive stool specimens for trophozoites and/or cysts of E. histolytica or G. lamblia by the merthiolate iodine formaldehyde (MIFC) technique were included. Criteria for cure were at least 10 negative stool specimens over 3 weeks after completing therapy. Fifty-three male patients (aged 9-65 years) had E. histolytica infection. Seventeen received metronidazole (1.5 g daily for 10 days), 18 tinidazole (1.5 g daily for 10 days) and 18 ornidazole (1 g daily for 10 days). Metronidazole yielded 88%, tinidazole 67% and ornidazole 94% cure rates. Side reactions were minor. Eighty patients had G. lamblia infection, of whom 20 received metronidazole (0.5 g daily for 10 days), 30 tinidazole (single 2 g dose) and 30 ornidazole (single 1 g dose). Cure rates were 95% for metronidazole, 90% for tinidazole and 97% for ornidazole with no side reactions.

摘要

对甲硝唑、替硝唑和奥硝唑治疗溶组织内阿米巴或蓝氏贾第鞭毛虫肠道感染的患者进行了比较。仅纳入通过硫柳汞碘甲醛（MIFC）技术检测到粪便标本中溶组织内阿米巴或蓝氏贾第鞭毛虫滋养体和/或包囊呈阳性的患者。治愈标准为完成治疗后3周内至少有10份粪便标本呈阴性。53名男性患者（年龄9 - 65岁）感染了溶组织内阿米巴。17人接受甲硝唑治疗（每日1.5克，共10天），18人接受替硝唑治疗（每日1.5克，共10天），18人接受奥硝唑治疗（每日1克，共10天）。甲硝唑的治愈率为88%，替硝唑为67%，奥硝唑为94%。副作用较小。80名患者感染了蓝氏贾第鞭毛虫，其中20人接受甲硝唑治疗（每日0.5克，共10天），30人接受替硝唑治疗（单次2克剂量），30人接受奥硝唑治疗（单次1克剂量）。甲硝唑的治愈率为95%，替硝唑为90%，奥硝唑为97%，且无副作用。