用于检测癌性外泌体的适配体传感器
Aptasensors for Cancerous Exosome Detection.
作者信息
Li Jin, Xie Sitao, Qu Fengli, Tan Weihong
机构信息
The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, China.
出版信息
Methods Mol Biol. 2022;2504:3-20. doi: 10.1007/978-1-0716-2341-1_1.
Cancerous exosomes that carry multiple biomarkers are attractive targets for the early diagnosis and therapy of cancer. As one of the powerful molecular recognition tools, aptamers with excellent binding affinity and specificity toward biomarkers have been exploited to construct various aptamer-based biosensors (aptasensors) for exosome detection. Here, we review recent advances in aptasensors for the detection of cancerous exosomes. We first discuss the importance and potential of cancerous exosomes in cancer diagnosis and then summarize some conventional aptasensors from the perspective of biomarker recognition and signal collection strategies. Finally, we comment on the outlook for aptasensor research and new directions for cancerous exosome detection.
携带多种生物标志物的癌性外泌体是癌症早期诊断和治疗的有吸引力的靶点。作为强大的分子识别工具之一，对生物标志物具有优异结合亲和力和特异性的适配体已被用于构建各种基于适配体的生物传感器（适配体传感器）用于外泌体检测。在此，我们综述了用于检测癌性外泌体的适配体传感器的最新进展。我们首先讨论癌性外泌体在癌症诊断中的重要性和潜力，然后从生物标志物识别和信号收集策略的角度总结一些传统的适配体传感器。最后，我们对适配体传感器研究的前景以及癌性外泌体检测的新方向进行评论。
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