脂肪乳剂诱导的小儿神经母细胞瘤切除术后高血压：病例报告及文献复习。
Lipid emulsion-induced hypertension post resection of pediatric neuroblastoma: a case report and literature review.
机构信息
Department of Pharmacy, Children's Hospital of Nanjing Medical University, 210008, Nanjing, China.
Department of Oncology, Children's Hospital of Nanjing Medical University, 210008, Nanjing, China.
出版信息
BMC Pediatr. 2022 Apr 25;22(1):224. doi: 10.1186/s12887-022-03278-2.
BACKGROUND
Parenteral Nutrition (PN) is preferred when patient is unable to eat. Most clinically widely used lipid emulsion is now attracting more attention in its stability and adverse reactions. We report here the first case of lipid emulsions caused hypertension.
CASE PRESENTATION
A 1.5 years old girl was diagnosed with neuroblastoma and underwent chemotherapy subsequently followed by resection surgery. She received PN for nutritional support after surgery. with the initiation of PN, this patient developed hypertension. Possible causes of hypertension were evaluated. After the discontinuation of lipid emulsions in PN, her hypertensive symptoms ceased. The lipid emulsion was therefore considered as the cause of her hypertension.
CONCLUSIONS
The pathogenesis of hypertension caused by fatty milk is possibly associated with increased production of reactive oxygen species, increased oxidative stress and vasoconstriction.
背景
当患者无法进食时，通常会选择肠外营养（PN）。目前，临床上应用最广泛的脂肪乳剂在其稳定性和不良反应方面引起了更多关注。我们在此报告首例脂肪乳剂引起的高血压病例。
病例介绍
一名 1.5 岁女孩被诊断为神经母细胞瘤，并随后接受了化疗，接着进行了手术切除。术后，她接受 PN 进行营养支持。在开始 PN 后，该患者出现了高血压。对高血压的可能病因进行了评估。停用 PN 中的脂肪乳剂后，她的高血压症状停止。因此，脂肪乳剂被认为是导致她高血压的原因。
结论
脂肪乳引起高血压的发病机制可能与活性氧生成增加、氧化应激增加和血管收缩有关。
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