负载姜黄素的聚乙二醇化介孔二氧化硅纳米颗粒用于有效的光动力疗法。
Curcumin-loaded PEGylated mesoporous silica nanoparticles for effective photodynamic therapy.
作者信息
Kuang Gaizhen, Zhang Qingfei, He Shasha, Liu Ying
机构信息
Department of Medical Oncology, Affiliated Cancer Hospital of Zhengzhou University Zhengzhou 450008 P. R. China
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 P. R. China.
出版信息
RSC Adv. 2020 Jun 29;10(41):24624-24630. doi: 10.1039/d0ra04778c. eCollection 2020 Jun 24.
Curcumin (Cur) can be used as a photosensitizer in the photodynamic therapy (PDT) of cancer, but its low bioavailability limits further clinical application. A mesoporous silica-based drug delivery system (PEGylated mesoporous silica nanoparticles, MSN-PEG@Cur) was designed to solve the problem. The successful preparation of MSN-PEG@Cur was characterized by several physico-chemistry techniques. The endocytosis, ROS generation and anti-cancer efficacy of MSN-PEG@Cur were evaluated in detail step by step. The results indicated that MSN-PEG@Cur could be effectively endocytosed into cells and release Cur, which can promptly generate ROS upon irradiation, achieving effective PDT in cancer treatment. This MSNs-based drug delivery system provides an alternative strategy for Cur loading and PDT of cancer.
姜黄素（Cur）可作为癌症光动力疗法（PDT）中的光敏剂，但其低生物利用度限制了进一步的临床应用。为解决该问题，设计了一种基于介孔二氧化硅的药物递送系统（聚乙二醇化介孔二氧化硅纳米颗粒，MSN-PEG@Cur）。通过多种物理化学技术对MSN-PEG@Cur的成功制备进行了表征。逐步详细评估了MSN-PEG@Cur的内吞作用、活性氧生成及抗癌疗效。结果表明，MSN-PEG@Cur可有效内吞进入细胞并释放Cur，Cur在照射后可迅速产生活性氧，在癌症治疗中实现有效的光动力疗法。这种基于介孔二氧化硅纳米颗粒的药物递送系统为Cur负载及癌症光动力疗法提供了一种替代策略。
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