用于双模态癌症光疗的近红外无金属四（丁基氨基）酞菁纳米颗粒
Near-infrared and metal-free tetra(butylamino)phthalocyanine nanoparticles for dual modal cancer phototherapy.
作者信息
Wu Ying-Jie, Lv Fan-Hong, Kan Jing-Lan, Guan Qun, Xue Anqi, Wang Quanbo, Li Yan-An, Dong Yu-Bin
机构信息
College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University Jinan 250014 P. R. China
Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences) Jinan 250014 P. R. China.
出版信息
RSC Adv. 2020 Jul 9;10(43):25958-25965. doi: 10.1039/d0ra03898a. eCollection 2020 Jul 3.
Synergistic phototherapy combining photodynamic therapy (PDT) and photothermal therapy (PTT) based on near-infrared (NIR) dyes using a single light source offers the opportunity to treat diseases at deep locations. In this study, we reported human serum albumin (HSA)-involving tetra(butylamino)phthalocyanine (Pc)-based nanomaterials of HSA-α-Pc and HSA-β-Pc as highly efficient dual-phototherapy agents, namely 1(4),8(11),15(18),22(25)-tetra(butylamino)phthalocyanine (α-Pc) and 2(3),9(10),16(17),23(24)-tetra(butylamino)phthalocyanine (β-Pc). Both HSA-α-Pc and HSA-β-Pc showed excellent photothermal effects under a single NIR (808 nm) laser irradiation due to the fluorescence emission quenching of Pcs. Compared to HSA-β-Pc, HSA-α-Pc exhibited better singlet oxygen generation ability and its highly efficient PDT/PTT dual-phototherapy was also well evidenced and experiments under a single 808 nm laser irradiation. Overall, this approach would be viable for the fabrication of more new Pc-based metal-free nano agents for PDT/PTT synergistic phototherapy upon a single NIR light source.
基于近红外（NIR）染料并使用单一光源的光动力疗法（PDT）和光热疗法（PTT）相结合的协同光疗为治疗深部疾病提供了机会。在本研究中，我们报道了含人血清白蛋白（HSA）的基于四（丁基氨基）酞菁（Pc）的纳米材料HSA-α-Pc和HSA-β-Pc，即1(4),8(11),15(18),22(25)-四（丁基氨基）酞菁（α-Pc）和2(3),9(10),16(17),23(24)-四（丁基氨基）酞菁（β-Pc），作为高效的双光疗剂。由于酞菁的荧光发射猝灭，HSA-α-Pc和HSA-β-Pc在单一近红外（808 nm）激光照射下均表现出优异的光热效应。与HSA-β-Pc相比，HSA-α-Pc表现出更好的单线态氧生成能力，其高效的PDT/PTT双光疗在单一808 nm激光照射下的实验中也得到了充分证明。总体而言，这种方法对于制备更多基于Pc的无金属纳米剂用于单一近红外光源下的PDT/PTT协同光疗是可行的。
Zotero 插件