Wu Yu, Hu Honghai, Dai Xiaofeng, Che Huilian, Zhang Hong
Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture Beijing 100193 China
College of Food Science and Nutritional Engineering, China Agricultural University Beijing 100083 China.
RSC Adv. 2019 Oct 17;9(57):33290-33301. doi: 10.1039/c9ra04867g. eCollection 2019 Oct 15.
Potatoes, as a prominent staple food, have exerted diverse intestinal health benefits, but few studies have addressed the gut microecology modulatory effects of consuming potatoes in realistic quantities. The objective of this study was to evaluate the effects of ingesting potatoes in different doses on body weight gain (BWG), food intake, short chain fatty acids (SCFAs), fecal microbiota, gut hormones, and colon morphology of healthy rats. Male Sprague-Dawley rats of 6-8 weeks old were randomized to five groups and fed AIN-93 G or diets containing graded concentrations of potato powder (low, medium, high, and higher) for 7 weeks. Accordingly, the final body weight was significantly lower for rats fed the high and/or higher potato diets than their control counterparts ( < 0.05). Potato intervention caused a significant dose-dependent increment in full cecum, and SCFAs production. The relative abundance of "S24-7" (order Bacteroidales), , "NK3B31" (family Prevotellaceae), , and _1 increased in high and higher potato diets. Furthermore, a Spearman's correlation analysis revealed that was negatively correlated with BWG, triglyceride (TG), and low-density lipoproteins (LDL). The maximum number of goblet cells, longest crypt depth, and highest level of PYY were found in the distal colon of rats fed higher potato diets. The results suggested that potato powder could provide the potential for hopeful impact on weight control.
土豆作为一种重要的主食，对肠道健康具有多种益处，但很少有研究探讨食用实际数量的土豆对肠道微生态的调节作用。本研究的目的是评估不同剂量摄入土豆对健康大鼠体重增加（BWG）、食物摄入量、短链脂肪酸（SCFAs）、粪便微生物群、肠道激素和结肠形态的影响。将6 - 8周龄的雄性斯普拉格 - 道利大鼠随机分为五组，分别喂食AIN - 93 G或含有不同浓度土豆粉（低、中、高和更高）的日粮7周。相应地，喂食高剂量和/或更高剂量土豆日粮的大鼠最终体重显著低于其对照组（<0.05）。土豆干预导致盲肠饱满度和SCFAs产量显著呈剂量依赖性增加。在高剂量和更高剂量土豆日粮组中，“S24 - 7”（拟杆菌目）、“NK3B31”（普雷沃氏菌科）和_1的相对丰度增加。此外，Spearman相关性分析显示， 与BWG、甘油三酯（TG）和低密度脂蛋白（LDL）呈负相关。在喂食更高剂量土豆日粮的大鼠远端结肠中发现杯状细胞数量最多、隐窝深度最长和PYY水平最高。结果表明，土豆粉可能对体重控制有积极影响。
