Cai Bianyun, Jiang Nan, Tan Peijie, Hou Yi, Li Yubao, Zhang Li, Zhu Songsong
Analytical & Testing Center, Sichuan University Chengdu 610065 China
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University Chengdu 610065 China
RSC Adv. 2019 Dec 13;9(70):41311-41318. doi: 10.1039/c9ra08168b. eCollection 2019 Dec 9.
In this study, a series of hierarchical micro/nanoscaled titanium phosphate (TiP) coatings possessing various surface morphologies were successfully fabricated on titanium (Ti) discs. The hydrothermal reactions of Ti discs in hydrogen peroxide (HO) and phosphoric acid (HPO) mixed solution yield diverse topographies such as hemispheric clump, cylindrical rod, spherical walnut, micro/nano grass, micro/nano sheet, and fibrous network. And their crystal structures were mainly composed of Ti(HPO)·0.5HO, (TiO)PO, HTiPO, Ti(HPO) and TiO. The morphology and crystal shape of the TiP coatings depend strongly on the mass ratio of HO/HPO, reaction temperature and water content. Besides, the formation mechanism of TiP coatings with diverse morphologies was explored from the perspective of energetics and crystallography. The mechanism exploration paved the way for custom-making TiP coatings with desirable micro/nanoscaled morphologies to meet specific application purposes. The cytological performances of TiP coatings were also evaluated by co-culturing with rat bone marrow stromal cells (BMSCs), demonstrating a positive prospect for their use in bone tissue engineering.
在本研究中，一系列具有不同表面形貌的分级微/纳米尺度磷酸钛（TiP）涂层成功制备在钛（Ti）盘上。钛盘在过氧化氢（H₂O₂）和磷酸（H₃PO₄）混合溶液中的水热反应产生了多种形貌，如半球形团块、圆柱形棒、球形核桃、微/纳米草、微/纳米片和纤维网络。并且它们的晶体结构主要由Ti(HPO₄)₂·0.5H₂O、(TiO)₂PO₄、HTiPO₄、Ti(H₂PO₄)₂和TiO₂组成。TiP涂层的形貌和晶体形状强烈依赖于H₂O₂/H₃PO₄的质量比、反应温度和含水量。此外，从能量学和晶体学的角度探索了具有不同形貌的TiP涂层的形成机制。该机制探索为定制具有理想微/纳米尺度形貌的TiP涂层以满足特定应用目的铺平了道路。还通过与大鼠骨髓基质细胞（BMSCs）共培养评估了TiP涂层的细胞学性能，表明其在骨组织工程中的应用具有积极前景。
