普遍存在于灵长类动物前额叶-杏仁核网络中的交互社交凝视神经元。
Widespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks.
机构信息
Department of Psychology, Yale University, New Haven, CT 06520, USA; Department of Psychology, University of Turin, 10124 Torino, Italy.
Department of Psychology, Yale University, New Haven, CT 06520, USA.
出版信息
Neuron. 2022 Jul 6;110(13):2183-2197.e7. doi: 10.1016/j.neuron.2022.04.013. Epub 2022 May 10.
Social gaze interaction powerfully shapes interpersonal communication. However, compared with social perception, very little is known about the neuronal underpinnings of real-life social gaze interaction. Here, we studied a large number of neurons spanning four regions in primate prefrontal-amygdala networks and demonstrate robust single-cell foundations of interactive social gaze in the orbitofrontal, dorsomedial prefrontal, and anterior cingulate cortices, in addition to the amygdala. Many neurons in these areas exhibited high temporal heterogeneity for social discriminability, with a selectivity bias for looking at a conspecific compared with an object. Notably, a large proportion of neurons in each brain region parametrically tracked the gaze of self or other, providing substrates for social gaze monitoring. Furthermore, several neurons displayed selective encoding of mutual eye contact in an agent-specific manner. These findings provide evidence of widespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks during social gaze interaction.
社会目光互动有力地塑造了人际沟通。然而，与社会感知相比，人们对现实生活中社会目光互动的神经基础知之甚少。在这里，我们研究了灵长类动物前额叶-杏仁核网络中跨越四个区域的大量神经元，并证明了眶额皮质、背内侧前额叶和前扣带皮质以及杏仁核中存在强大的互动社会目光的单细胞基础。这些区域中的许多神经元对社会可区分性表现出高度的时间异质性，与看同类相比，对看物体具有选择性偏见。值得注意的是，每个脑区的很大一部分神经元参数化地跟踪自我或他人的目光，为社会目光监测提供了基础。此外，一些神经元以特定于主体的方式选择性地编码相互眼神接触。这些发现为灵长类动物前额叶-杏仁核网络在社会目光互动过程中广泛实施互动社会目光神经元提供了证据。
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