Inczefi Orsolya, Bacsur Péter, Resál Tamás, Keresztes Csilla, Molnár Tamás
Department of Gastroenterology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Department for Medical Communication and Translation Studies, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Front Nutr. 2022 Apr 25;9:718710. doi: 10.3389/fnut.2022.718710. eCollection 2022.
The leakage of the intestinal barrier and the disruption of the gut microbiome are increasingly recognized as key factors in different pathophysiological conditions, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), chronic liver diseases, obesity, diabetes mellitus, types of cancer, and neuropsychiatric disorders. In this study, the mechanisms leading to dysbiosis and "leaky gut" are reviewed, and a short summary of the current knowledge regarding different diseases is provided. The simplest way to restore intestinal permeability and the microbiota could be ideal nutrition. Further therapeutic options are also available, such as the administration of probiotics or postbiotics or fecal microbiota transplantation.
肠屏障渗漏和肠道微生物群紊乱日益被认为是不同病理生理状况的关键因素，如肠易激综合征（IBS）、炎症性肠病（IBD）、慢性肝病、肥胖症、糖尿病、各类癌症以及神经精神疾病。在本研究中，对导致微生物群失调和“肠漏”的机制进行了综述，并提供了有关不同疾病的现有知识的简短总结。恢复肠道通透性和微生物群的最简单方法可能是理想的营养。还有其他治疗选择，如给予益生菌、后生元或进行粪便微生物群移植。
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