乳腺癌中的肿瘤干细胞。
Tumour Stem Cells in Breast Cancer.
机构信息
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5, Kooperativny Street, 634050 Tomsk, Russia.
Laboratory of Genetic Technologies, Siberian State Medical University, 2, Moscow Tract, 634050 Tomsk, Russia.
出版信息
Int J Mol Sci. 2022 May 2;23(9):5058. doi: 10.3390/ijms23095058.
Tumour stem cells (CSCs) are a self-renewing population that plays important roles in tumour initiation, recurrence, and metastasis. Although the medical literature is extensive, problems with CSC identification and cancer therapy remain. This review provides the main mechanisms of CSC action in breast cancer (BC): CSC markers and signalling pathways, heterogeneity, plasticity, and ecological behaviour. The dynamic heterogeneity of CSCs and the dynamic transitions of CSC non-CSCs and their significance for metastasis are considered.
肿瘤干细胞（CSC）是一类具有自我更新能力的细胞群体，在肿瘤的发生、复发和转移中发挥着重要作用。尽管医学文献非常丰富，但 CSC 的鉴定和癌症治疗仍然存在问题。本文综述了 CSC 在乳腺癌（BC）中的主要作用机制：CSC 标志物和信号通路、异质性、可塑性和生态行为。考虑了 CSCs 的动态异质性以及 CSC 非 CSCs 的动态转化及其对转移的意义。
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