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从 和 中提取的生物活性化合物的特性、 通过 提取物生产的银纳米粒子及其生物学特性。

Characterization of Bioactive Compounds from and , Silver Nanoparticles' Production by Extract, and Their Biological Properties.

机构信息

Department of Pharmacology, College of Pharmacy, Najran University, Najran 66462, Saudi Arabia.

Department of Biotechnology, KLE Technological University, BVB Campus, Hubballi 580031, Karnataka, India.

出版信息

Molecules. 2022 Apr 22;27(9):2715. doi: 10.3390/molecules27092715.

Abstract

The applications of bioactive compounds from medicinal plants as therapeutic drugs are largely increasing. The present study selected the bioactive compounds from () and () to assess their phytochemicals, proteins, and biological activity. The plant material was collected, and extraction performed as per the standard procedure. Qualitative analysis was undertaken, and identification of functional organic groups was performed by FTIR and HPLC. Antibacterial, anticancer, antioxidant, antihyperglycemic, antihyperlipidemic, and inhibition kinetics studies for enzymes were performed to assess the different biological activities. Flavonoids and phenols were present in a significant amount in both the selected plants. showed significant antimicrobial activity against , , and , with minimum inhibition zones (MIZ) of 24, 22, and 20 mm, respectively. strongly inhibited all the tested pathogenic bacteria with maximum and minimum MIZ of 32 and 17 mm. silver nanoparticles also exhibited potent antimicrobial activity. Both extracts showed substantial antioxidant, antihyperlipidemic, antidiabetic, anticancer (MCF-7), and anti-urease (antiulcer) properties. To conclude, these plants can be used to treat hyperlipidemia, diabetes, cancer, and gastrointestinal ulcers. They can also serve as antimicrobial and antioxidant agents. Thus, the studied plants must be exploited cost-effectively to generate therapeutic drugs for various diseases.

摘要

药用植物生物活性化合物作为治疗药物的应用正在大幅增加。本研究从()和()中选择生物活性化合物,以评估其植物化学物质、蛋白质和生物活性。按照标准程序采集植物材料并进行提取。通过傅里叶变换红外光谱(FTIR)和高效液相色谱(HPLC)进行定性分析和功能有机基团的鉴定。进行了抗菌、抗癌、抗氧化、抗高血糖、抗高血脂和酶抑制动力学研究,以评估不同的生物活性。两种选定的植物中均含有大量的类黄酮和酚类化合物。()对、和表现出显著的抗菌活性,最小抑菌圈(MIZ)分别为 24、22 和 20mm。()强烈抑制所有测试的致病菌,最大和最小 MIZ 分别为 32 和 17mm。银纳米粒子也表现出很强的抗菌活性。两种提取物均表现出较强的抗氧化、抗高血脂、抗糖尿病、抗癌(MCF-7)和抗脲酶(抗溃疡)特性。总之,这些植物可用于治疗高血脂、糖尿病、癌症和胃肠道溃疡。它们还可以作为抗菌和抗氧化剂。因此,必须经济有效地开发这些研究植物,以生成治疗各种疾病的药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31f5/9105112/e960302af800/molecules-27-02715-g001.jpg

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