氰化物解毒剂对氨基苯丙酮（PAPP）静脉输注氰化物的影响。
Effect of p-aminopropiophenone (PAPP), a cyanide antidote, on cyanide given by intravenous infusion.
作者信息
Bright J E, Marrs T C
出版信息
Hum Toxicol. 1987 Mar;6(2):133-7. doi: 10.1177/096032718700600205.
PMID:3557470
Abstract
Beagle bitches were infused with potassium cyanide solution after protection with p-aminopropiophenone (PAPP). Methaemoglobin levels fell very rapidly after the start of the infusion. Whole blood and plasma cyanide estimations revealed that most of the cyanide was sequestered inside the red cells. Animals survived a supralethal dose of cyanide when protected with PAPP.
摘要
在用对氨基苯丙酮（PAPP）进行保护后，给比格犬母犬输注氰化钾溶液。输注开始后，高铁血红蛋白水平迅速下降。全血和血浆氰化物测定显示，大部分氰化物被隔离在红细胞内。在用PAPP保护时，动物能在超致死剂量的氰化物作用下存活。
相似文献
1
Effect of p-aminopropiophenone (PAPP), a cyanide antidote, on cyanide given by intravenous infusion.
Hum Toxicol. 1987 Mar;6(2):133-7. doi: 10.1177/096032718700600205.
2
Effect on blood and plasma cyanide levels and on methaemoglobin levels of cyanide administered with and without previous protection using PAPP.
Hum Toxicol. 1987 Mar;6(2):139-45. doi: 10.1177/096032718700600206.
3
Kinetics of methaemoglobin production. (2). Kinetics of the cyanide antidote p-aminopropiophenone during oral administration.
Hum Toxicol. 1986 Sep;5(5):303-7. doi: 10.1177/096032718600500502.
4
The formation of methaemoglobin by 4-aminopropiophenone (PAPP) and 4-(N-hydroxy) aminopropiophenone.
Hum Exp Toxicol. 1991 May;10(3):183-8. doi: 10.1177/096032719101000306.
5
Kinetics of methaemoglobin production. (1). Kinetics of methaemoglobinaemia induced by the cyanide antidotes, p-aminopropiophenone, p-hydroxyaminopropiophenone or p-dimethylaminophenol after intravenous administration.
Hum Toxicol. 1986 Sep;5(5):295-301. doi: 10.1177/096032718600500501.
6
Pharmacokinetics and kinetic-dynamic modelling of aminophenones as methaemoglobin formers.
J Pharm Pharmacol. 1997 Mar;49(3):282-7. doi: 10.1111/j.2042-7158.1997.tb06796.x.
7
Effects of sodium cyanide upon swimming performance in guinea-pigs and the conferment of protection by pretreatment with p-aminopropiophenone.
Neurobehav Toxicol Teratol. 1986 Mar-Apr;8(2):171-8.
8
Sex differences in the production of methaemoglobinaemia by 4-aminopropiophenone.
Xenobiotica. 1987 Jan;17(1):79-83. doi: 10.3109/00498258709047177.
9
Operant leverpressing and wheelrunning were differentially reduced by PAPP (p-aminopropiophenone)-induced methemoglobinemia.
Pharmacol Biochem Behav. 2007 Oct;87(4):444-52. doi: 10.1016/j.pbb.2007.05.021. Epub 2007 Jun 7.
10
Cyanide release from sodium nitroprusside in the dog.
Anesthesiology. 1977 Mar;46(3):196-201. doi: 10.1097/00000542-197703000-00007.
Zotero 插件