压痕模板法制备具有可控凹面的多面体颗粒。

Polyhedral Particles with Controlled Concavity by Indentation Templating.

机构信息

Department of Bioengineering and Therapeutic Sciences University of California, San Francisco 1700 Fourth Street, San Francisco, California 94158, United States.

Chan Zuckerberg Biohub 499 Illinois Street, San Francisco, California 94158, United States.

出版信息

Anal Chem. 2022 May 31;94(21):7475-7482. doi: 10.1021/acs.analchem.1c04884. Epub 2022 May 16.

DOI:10.1021/acs.analchem.1c04884

PMID:35578791

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9161221/

Abstract

Current methods for fabricating microparticles offer limited control over size and shape. Here, we demonstrate a droplet microfluidic method to form polyhedral microparticles with controlled concavity. By manipulating Laplace pressure, buoyancy, and particle rheology, we generate microparticles with diverse shapes and curvatures. Additionally, we demonstrate the particles provide increased capture efficiency when used for particle-templated emulsification. Our approach enables microparticles with enhanced chemical and biological functionality.

摘要

目前用于制造微粒的方法对尺寸和形状的控制有限。在这里，我们展示了一种液滴微流控方法，可形成具有受控凹度的多面体形微粒。通过操纵拉普拉斯压力、浮力和颗粒流变性，我们生成了具有不同形状和曲率的微粒。此外，我们还证明了当这些颗粒用于颗粒模板乳化时，它们具有更高的捕获效率。我们的方法使具有增强的化学和生物学功能的微粒成为可能。