Department of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Department of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA..
Biochim Biophys Acta Mol Cell Res. 2022 Sep;1869(9):119293. doi: 10.1016/j.bbamcr.2022.119293. Epub 2022 May 16.
The ubiquitous secondary messengers, Ca and cAMP, play a vital role in shaping a diverse array of physiological processes. More significantly, accumulating evidence over the past several decades underpin extensive crosstalk between these two canonical messengers in discrete sub-cellular nanodomains across various cell types. Within such specialized nanodomains, each messenger fine-tunes signaling to maintain homeostasis by manipulating the activities of cellular machinery accountable for the metabolism or activity of the complementary pathway. Interaction between these messengers is ensured by scaffolding proteins which tether components of the signaling machinery in close proximity. Disruption of dynamic communications between Ca and cAMP at these loci consequently is linked to several pathological conditions. This review summarizes recent novel mechanisms underlying effective crosstalk between Ca and cAMP in such nanodomains.
普遍存在的第二信使 Ca 和 cAMP 在塑造多种生理过程中起着至关重要的作用。更重要的是，过去几十年积累的证据表明，这两种经典信使在各种细胞类型的离散亚细胞纳米域中存在广泛的串扰。在这些专门的纳米域中，每种信使通过操纵负责互补途径代谢或活性的细胞机制的活性来微调信号传递以维持体内平衡。这些信使之间的相互作用是通过支架蛋白来保证的，这些支架蛋白将信号机制的组件紧密地连接在一起。因此，这些部位 Ca 和 cAMP 之间动态通讯的中断与几种病理状况有关。本综述总结了最近关于 Ca 和 cAMP 在这些纳米域中有效串扰的新机制。
