Udholm Nichlas, Rex Christian Emil, Fuglsang Milos, Lundbye-Christensen Søren, Bille Jesper, Udholm Sebastian
Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital Skejby, Aarhus, Denmark.
Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital Skejby, Aarhus, Denmark.
Sleep Med. 2022 Aug;96:64-69. doi: 10.1016/j.sleep.2022.04.003. Epub 2022 Apr 13.
In this nationwide study, we investigate the risk and severity of all road traffic accidents in patients with obstructive sleep apnea (OSA).
We used the unique Danish registries to identify all Danish citizens receiving a diagnosis of OSA between 1995 and 2015. As a reference cohort, we randomly selected 10 sex- and age-matched citizens for each patient. We used Poisson regression to calculate the incidens rate ratio (IRR) for all road traffic accidents (motor vehicle, bicycle, and pedestrian) in both groups, and Cox proportional regression analysis to compare risk of first motor vehicle accident. Lastly, we used Fischers' Exact test to compare severity of motor vehicle accident between the two groups- RESULTS: We identified 48,168 patients with OSA, covering up to 24 years of follow-up. Patients with OSA had an increased risk of road traffic accidents when compared with the reference cohort (hazard ratio, 1.15; 95% CI, 1.10-1.20; IRR: 1.19; 95% CI, 1.14-1.29), especially motor vehicle accidents (hazard ratio, 1.29; 95% CI, 1.18-1.39; IRR 1.30; 95% CI, 1.20-1.42). The risk of accidents as pedestrian or bicyclist were not increased. Further, patients with OSA had a tendency to be involved in more severe motor vehicle accidents.
This is the first nationwide study to estimate the risk of all road traffic accidents in patients with OSA. Our estimates show that patients with OSA have an increased risk of motor vehicle accidents, and greater severity of accidents, when compared with a large reference cohort.
在这项全国性研究中，我们调查阻塞性睡眠呼吸暂停（OSA）患者发生所有道路交通事故的风险及严重程度。
我们利用丹麦独特的登记系统，识别出1995年至2015年间所有被诊断为OSA的丹麦公民。作为对照队列，我们为每位患者随机选取10名性别和年龄匹配的公民。我们使用泊松回归计算两组中所有道路交通事故（机动车、自行车和行人事故）的发病率比值比（IRR），并使用Cox比例回归分析比较首次机动车事故的风险。最后，我们使用费舍尔精确检验比较两组机动车事故的严重程度。结果：我们识别出48168例OSA患者，随访时间长达24年。与对照队列相比，OSA患者发生道路交通事故的风险增加（风险比，1.15；95%置信区间，1.10 - 1.20；IRR：1.19；95%置信区间，1.14 - 1.29），尤其是机动车事故（风险比，1.29；95%置信区间，1.18 - 1.39；IRR 1.30；95%置信区间，1.20 - 1.42）。作为行人或骑自行车者发生事故的风险并未增加。此外，OSA患者发生更严重机动车事故的倾向更大。
这是第一项全国性研究，旨在评估OSA患者发生所有道路交通事故的风险。我们的评估表明，与一个大型对照队列相比，OSA患者发生机动车事故的风险增加，且事故严重程度更高。
