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2021年美国与新鲜、软质西班牙风味奶酪相关的单核细胞增生李斯特菌感染多州暴发

Multistate Outbreak of Listeria monocytogenes Infections Linked to Fresh, Soft Hispanic-Style Cheese - United States, 2021.

作者信息

Palacios Alexandra, Otto Mark, Flaherty Eileen, Boyle Michelle M, Malec Lenka, Holloman Kelsey, Low Mabel, Wellman Allison, Newhart Corinne, Gollarza Lauren, Weeks Tracey, Muyombwe Anthony, Lozinak Kristen, Kafka Erin, O'Halloran Daniel, Rozza Teresa, Nicholas David, Ivory Stranjae, Kreil Katherine, Huffman Jasmine, Gieraltowski Laura, Conrad Amanda

出版信息

MMWR Morb Mortal Wkly Rep. 2022 May 27;71(21):709-712. doi: 10.15585/mmwr.mm7121a3.

Abstract

Listeriosis is a serious infection usually caused by eating food contaminated with the bacterium Listeria monocytogenes. An estimated 1,600 persons become ill with listeriosis each year, among whom approximately 260 die. Persons at higher risk for listeriosis include pregnant persons and their newborns, adults aged ≥65 years, and persons with weakened immune systems. Persons with invasive listeriosis usually report symptoms starting 1-4 weeks after eating food contaminated with L. monocytogenes; however, some persons who become infected have reported symptoms starting as late as 70 days after exposure or as early as the same day of exposure (1). On January 29, 2021, PulseNet, the national molecular subtyping surveillance network coordinated by CDC, identified a multistate cluster of three L. monocytogenes infections: two from Maryland and one from Connecticut (2). CDC, the Food and Drug Administration (FDA), and state and local partners began an investigation on February 1, 2021. A total of 13 outbreak-related cases were eventually identified from four states. All patients reported Hispanic ethnicity; 12 patients were hospitalized, and one died. Rapid food testing and record collection by regulatory agencies enabled investigators to identify a brand of queso fresco made with pasteurized milk as the likely source of the outbreak, leading to an initial product recall on February 19, 2021. Fresh, soft Hispanic-style cheeses made with pasteurized milk are a well-documented source of listeriosis outbreaks. These cheeses can be contaminated with L. monocytogenes unless stringent hygienic controls are implemented, and the processing environment is monitored for contamination (3). U.S. public health agencies should establish or improve communications, including new methods of disseminating information that also effectively reach Hispanic populations, to emphasize the risk from eating fresh, soft Hispanic-style cheeses, even those made with pasteurized milk.

摘要

李斯特菌病是一种严重的感染病,通常由食用被产单核细胞李斯特菌污染的食物引起。据估计,每年有1600人感染李斯特菌病,其中约260人死亡。感染李斯特菌病风险较高的人群包括孕妇及其新生儿、65岁及以上的成年人以及免疫系统较弱的人。侵袭性李斯特菌病患者通常在食用被产单核细胞李斯特菌污染的食物后1至4周开始出现症状;然而,一些感染者报告症状最早在接触后70天出现,最晚在接触当天出现(1)。2021年1月29日,由美国疾病控制与预防中心协调的国家分子分型监测网络PulseNet识别出三例产单核细胞李斯特菌感染的多州聚集性病例:两例来自马里兰州,一例来自康涅狄格州(2)。美国疾病控制与预防中心、食品药品监督管理局(FDA)以及州和地方合作伙伴于2021年2月1日开始调查。最终从四个州确定了13例与此次疫情相关的病例。所有患者均为西班牙裔;12名患者住院治疗,1人死亡。监管机构通过快速食品检测和记录收集,使调查人员确定一种用巴氏杀菌牛奶制作的新鲜奶酪品牌可能是此次疫情的源头,从而于2021年2月19日进行了首次产品召回。用巴氏杀菌牛奶制作的新鲜、软质西班牙风味奶酪是有充分记录的李斯特菌病疫情源头。除非实施严格的卫生控制措施并监测加工环境是否受到污染,这些奶酪可能会被产单核细胞李斯特菌污染(3)。美国公共卫生机构应建立或改善沟通方式,包括采用能有效覆盖西班牙裔人群的新信息传播方法,以强调食用新鲜、软质西班牙风味奶酪(即使是用巴氏杀菌牛奶制作的)所带来的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7833/9153464/1d25758bc560/mm7121a3-F.jpg

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