GPR35 的表达模式与男性结直肠癌患者的总生存相关。
The GPR35 expression pattern is associated with overall survival in male patients with colorectal cancer.
机构信息
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland.
Roche Polska Sp. z o.o., Warsaw, Poland.
出版信息
Pharmacol Rep. 2022 Aug;74(4):709-717. doi: 10.1007/s43440-022-00371-2. Epub 2022 May 27.
BACKGROUND
G protein-coupled receptor 35 (GPR35) is involved in the carcinogenesis; however, limited data exist on its relevance for overall survival (OS) and disease-specific survival (DSS) in patients with cancer.
METHODS
We have examined The Cancer Genome Atlas dataset to check the relations between GPR35 expression pattern and OS or DSS of patients with colorectal cancer (CRC).
RESULTS
The performed analysis showed a negative association between positive GPR35 expression Z score and OS in males, which remains statistically significant in advanced stages of colon (COAD) and rectal (READ) adenocarcinoma combined.
CONCLUSIONS
These findings suggest the prognostic value of early testing of GPR35 in male patients with an increased risk of CRC development and warrant further clinical confirmation.
背景
G 蛋白偶联受体 35（GPR35）参与了癌症的发生；然而，目前关于其在癌症患者的总生存（OS）和疾病特异性生存（DSS）中的相关性的数据有限。
方法
我们已经检查了癌症基因组图谱数据集，以检查 GPR35 表达模式与结直肠癌（CRC）患者的 OS 或 DSS 之间的关系。
结果
进行的分析显示，GPR35 阳性表达 Z 评分与男性的 OS 呈负相关，在结（COAD）和直肠（READ）腺癌联合的晚期阶段仍然具有统计学意义。
结论
这些发现表明，在 CRC 发展风险增加的男性患者中早期检测 GPR35 具有预后价值，需要进一步的临床证实。
Zotero 插件