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地奥司明在人类疾病中的潜在作用及治疗作用

Potential and Therapeutic Roles of Diosmin in Human Diseases.

作者信息

Huwait Etimad, Mobashir Mohammad

机构信息

Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah 22254, Saudi Arabia.

Cell Culture Lab, Experimental Biochemistry Unit, King Fahad Medical Research Centre, King Abdulaziz University, Jeddah 22252, Saudi Arabia.

出版信息

Biomedicines. 2022 May 6;10(5):1076. doi: 10.3390/biomedicines10051076.

Abstract

Because of their medicinal characteristics, effectiveness, and importance, plant-derived flavonoids have been a possible subject of research for many years, particularly in the last decade. Plants contain a huge number of flavonoids, and Diosmin, a flavone glycoside, is one of them. Numerous and studies have validated Diosmin's extensive range of biological capabilities which present antioxidative, antihyperglycemic, anti-inflammatory, antimutagenic, and antiulcer properties. We have presented this review work because of the greater biological properties and influences of Diosmin. We have provided a brief overview of Diosmin, its pharmacology, major biological properties, such as anti-cancer, anti-diabetic, antibacterial, anticardiovascular, liver protection, and neuroprotection, therapeutic approach, potential Diosmin targets, and pathways that are known to be associated with it.

摘要

由于植物来源的黄酮类化合物具有药用特性、有效性和重要性,多年来一直是研究的潜在对象,尤其是在过去十年。植物中含有大量的黄酮类化合物,而地奥司明,一种黄酮糖苷,就是其中之一。众多研究已经证实了地奥司明具有广泛的生物学功能,包括抗氧化、抗高血糖、抗炎、抗诱变和抗溃疡特性。由于地奥司明具有更强的生物学特性和影响,我们撰写了这篇综述。我们简要概述了地奥司明、其药理学、主要生物学特性,如抗癌、抗糖尿病、抗菌、抗心血管、肝脏保护和神经保护作用、治疗方法、潜在的地奥司明靶点以及已知与之相关的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad43/9138579/65991faf782c/biomedicines-10-01076-g001.jpg

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