Board J A, Rosenberg S M, Smeltzer J S
South Med J. 1987 Apr;80(4):483-6. doi: 10.1097/00007611-198704000-00019.
Sixteen women with hirsutism used spironolactone, 100 mg daily without interruption, plus norethindrone (1 mg) and ethinyl estradiol (35 mg) for 21 of each 28 days. Clinical improvement occurred in 11 of the 16 patients and also in an additional patient when the dose of spironolactone was increased to 200 mg daily. Spironolactone 100 mg daily plus norethindrone and ethinyl estradiol resulted in significant reduction in serum total testosterone, serum free testosterone, and percentage of free testosterone. Side effects were infrequent.
16名多毛症女性连续每日服用100毫克螺内酯，同时每28天中有21天服用炔诺酮（1毫克）和炔雌醇（35毫克）。16名患者中有11名临床症状得到改善，另外1名患者在将螺内酯剂量增至每日200毫克时症状也有所改善。每日100毫克螺内酯联合炔诺酮和炔雌醇可使血清总睾酮、血清游离睾酮及游离睾酮百分比显著降低。副作用较少见。
