Faculty of Health Sciences, Department of Nutrition and Dietetics, Near East University, Nicosia, Cyprus..
Faculty of Pharmacy, Department of Biochemistry, Near East University, Nicosia, Cyprus; Research Center of Experimental Health Sciences (DESAM), Near East University, Nicosia, Cyprus.
Nutr Res. 2022 Aug;104:82-90. doi: 10.1016/j.nutres.2022.04.007. Epub 2022 May 10.
Cellular senescence plays a key role in aging and age-related disease initiation. It is a highly dynamic and multistep process that can be stimulated by various stimuli, including cellular stress, DNA damage, telomere shortening, and oncogene activation. Also, senescence is a potent antitumor mechanism, by preventing the proliferation of cancerous cells. However, some of the senescent cells have apoptosis resistance and can cause recurrence in cancer. A new class of drugs termed senolytics selectively kill and eliminate senescent cells. In recent years, natural compounds such as quercetin have been discovered to be effective as senolytic agents. Quercetin is a phytochemical that has strong antioxidant properties and pro-apoptotic effects and has been investigated for many years. Additionally, it has great potential to be used as a senolytic agent. According to preclinical and early-phase clinical data of senolytic agent research, quercetin administration appears to be effective in preventing or alleviating cancer formation. In this paper, we review the importance of cellular senescence in carcinogenesis and the effects of quercetin on senescence, as well as quercetin's potential effects as a pro-apoptotic agent and suppressor of cancer cell proliferation.
细胞衰老在衰老和与年龄相关的疾病的发生中起着关键作用。它是一个高度动态和多步骤的过程，可以被各种刺激物刺激，包括细胞应激、DNA 损伤、端粒缩短和癌基因激活。此外，衰老还是一种有效的抗肿瘤机制，可以防止癌细胞的增殖。然而，一些衰老的细胞具有抗凋亡性，并且可能导致癌症复发。一类被称为衰老细胞选择性杀伤剂的新型药物可以选择性地杀死和消除衰老细胞。近年来，人们发现一些天然化合物，如槲皮素，作为衰老细胞选择性杀伤剂非常有效。槲皮素是一种具有很强抗氧化特性和促凋亡作用的植物化学物质，已经研究了很多年。此外，它作为衰老细胞选择性杀伤剂具有很大的应用潜力。根据衰老细胞选择性杀伤剂研究的临床前和早期临床数据，槲皮素的给药似乎可以有效地预防或缓解癌症的形成。在本文中，我们综述了细胞衰老在致癌作用中的重要性，以及槲皮素对衰老的影响，以及槲皮素作为促凋亡剂和抑制癌细胞增殖的潜在作用。
