London Womens Clinic, London, UK.
Curr Opin Obstet Gynecol. 2022 Jun 1;34(3):147-150. doi: 10.1097/GCO.0000000000000781.
To review the merits and limitations of current definitions of recurrent implantation failure (RIF), how they translate into estimates of incidence and to summarize how emerging concepts of individualizing the recognition of this condition can assist in changing the way RIF is identified, studied and managed.
The notion of a one size fits all definition of RIF is seen to be of limited clinical value, as the individual risk of repeated IVF failure has many determinants and causes. Novel approaches provide a means of identifying 'actionable' RIF in individual patients.
Uncertainties as to what constitutes, causes and defines RIF have served to limit progress in its management. A new approach promises to permit progress from the current impasse.
回顾目前复发性种植失败（RIF）定义的优缺点，以及它们如何转化为发病率的估计，并总结如何通过个体化认识这一疾病的新概念来帮助改变识别、研究和管理 RIF 的方式。
RIF 的一刀切定义概念被认为临床价值有限，因为重复试管婴儿失败的个体风险有许多决定因素和原因。新方法为识别个体患者的“可操作”RIF 提供了一种手段。
对于 RIF 的构成、原因和定义的不确定性限制了其管理的进展。一种新的方法有望打破当前的僵局。
