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调控 MHC II 免疫肽库可塑性的分子决定因素。

Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome.

机构信息

Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, United States.

Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, United States.

出版信息

Front Immunol. 2022 May 16;13:878271. doi: 10.3389/fimmu.2022.878271. eCollection 2022.

DOI:10.3389/fimmu.2022.878271
PMID:35651601
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9148998/
Abstract

In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented peptides, from MHC class II molecule polymorphisms to the recognition of different conformers, functional differences in endosomal processing along the endocytic tract, and the interplay between the MHC class II chaperones DM and DO. The sum of all these variables contributes, qualitatively and quantitatively, to the composition of the MHC II ligandome, altogether ensuring that the immunopeptidome landscape is highly sensitive to any changes in the composition of the intra- and extracellular proteome for a comprehensive survey of the microenvironment for MHC II presentation to CD4 T cells.

摘要

在过去的几年中，对几种小鼠和人类单倍型的 MHC 类 II（MHC-II）配体组分析的进展提高了我们对调节 MHC-II 呈递肽的范围和选择的分子成分的理解，从 MHC 类 II 分子多态性到对不同构象的识别、内体处理过程中的内体处理中的功能差异，以及 MHC 类 II 伴侣 DM 和 DO 之间的相互作用。所有这些变量的总和从质量和数量上共同构成了 MHC II 配体组，共同确保免疫肽组景观对细胞内和细胞外蛋白质组组成的任何变化都非常敏感，以全面研究 MHC II 呈递 CD4 T 细胞的微环境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faa/9148998/09f440fd2cbc/fimmu-13-878271-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faa/9148998/e057f68201bb/fimmu-13-878271-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faa/9148998/09f440fd2cbc/fimmu-13-878271-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faa/9148998/e057f68201bb/fimmu-13-878271-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6faa/9148998/09f440fd2cbc/fimmu-13-878271-g002.jpg

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