Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Kumiai Kosei Hospital, Gifu, Japan.
Cancer Sci. 2022 Aug;113(8):2839-2848. doi: 10.1111/cas.15455. Epub 2022 Jun 25.
Few large epidemiological studies have evaluated the association between dietary advanced glycation end products (AGEs) and cancer risk. We evaluated the relationship between dietary AGE intake and the incidence of total cancer and site-specific cancers in a population-based prospective study in Japan. Participants were 14,173 men and 16,549 women who were 35 years of age or older in 1992. Dietary intake was assessed via a validated food frequency questionnaire. Intake of the AGE N -carboxymethyl-lysine (CML) was estimated using databases of CML content in foods determined using ultraperformance liquid chromatography-tandem mass spectrometry. Cancer incidence was confirmed through regional population-based cancer registries. During a mean follow-up period of 13.3 years, 1954 men and 1477 women developed cancer. We did not observe a significant association between CML intake and the risk of total cancer in men or women. In men, compared with the lowest quartile of CML intake, the hazard ratios of liver cancer for the second, third, and highest quartiles were 1.69 (95% CI: 0.92-3.10), 1.48 (95% CI: 0.77-2.84), and 2.10 (95% CI: 1.10-3.98; trend p = 0.04). Conversely, a decreased relative risk of male stomach cancer was observed for the second and highest quartiles of CML intake versus the lowest quartile, with hazard ratios of 0.73 and 0.67, respectively (trend p = 0.08). Our finding on the potential harmfulness of consuming AGEs on liver cancer risk is intriguing and warrants further study.
很少有大型流行病学研究评估饮食中晚期糖基化终产物（AGEs）与癌症风险之间的关系。我们在日本进行的一项基于人群的前瞻性研究中，评估了饮食中 AGE 摄入量与总癌症和特定部位癌症发病率之间的关系。参与者为 1992 年年龄在 35 岁及以上的 14173 名男性和 16549 名女性。通过验证过的食物频率问卷评估饮食摄入量。使用超高效液相色谱-串联质谱法测定食物中 CML 含量的数据库来估计 N -羧甲基赖氨酸（CML）的摄入量。通过区域人群癌症登记处确认癌症发病率。在平均 13.3 年的随访期间，1954 名男性和 1477 名女性发生了癌症。我们没有观察到 CML 摄入量与男性或女性总癌症风险之间存在显著关联。在男性中，与 CML 摄入量最低的四分位数相比，肝癌的危险比为第二、第三和最高四分位数的 1.69（95% CI：0.92-3.10）、1.48（95% CI：0.77-2.84）和 2.10（95% CI：1.10-3.98；趋势 p=0.04）。相反，与最低四分位数相比，第二和最高四分位数的 CML 摄入量与男性胃癌的相对风险降低，危险比分别为 0.73 和 0.67（趋势 p=0.08）。我们关于摄入 AGE 对肝癌风险的潜在危害性的发现很有趣，值得进一步研究。
