Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine; Institute of Nephrology, Zhejiang University, Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, China.
Anji People's Hospital, Huzhou, China.
Ther Apher Dial. 2023 Feb;27(1):83-90. doi: 10.1111/1744-9987.13892. Epub 2022 Jun 29.
This study aimed to analyze the change of serum uric acid (SUA) level post peritoneal dialysis (PD), and the correlation between follow-up SUA and prognosis in patients with PD.
A total of 1402 patients with PD were evaluated. We graded SUA levels into four grades at baseline, 6 months, 12 months, 18 months, and 24 months post PD, and then compared all-cause mortality and cardiovascular mortality among patients with different SUA grades at each time point. Kaplan-Meier and Cox proportional-hazards regression models were used in the analysis.
The SUA levels were 7.97 ± 1.79, 7.12 ± 1.48, 7.05 ± 1.33, 7.01 ± 1.30, and 6.93 ± 1.26 mg/dl at baseline, 6, 12, 18, and 24 months, respectively. There was significant difference on all-cause mortality among patients with PD with different graded SUA levels at 6 months post PD (p = 0.010), and the all-cause mortality was lowest in patients with the grade of 5.65 mg/dl ≤ SUA <7.13 mg/dl.
SUA level decreased after PD during follow-up. At 6 months post PD, the grade of 5.65 mg/dl ≤ SUA <7.13 mg/dl was appropriate for better patients' survival.
本研究旨在分析腹膜透析（PD）后血清尿酸（SUA）水平的变化，以及随访 SUA 与 PD 患者预后的相关性。
共评估了 1402 例 PD 患者。我们在基线、6 个月、12 个月、18 个月和 24 个月时将 SUA 水平分为四个等级，然后比较每个时间点不同 SUA 等级患者的全因死亡率和心血管死亡率。采用 Kaplan-Meier 和 Cox 比例风险回归模型进行分析。
SUA 水平分别为 7.97±1.79、7.12±1.48、7.05±1.33、7.01±1.30 和 6.93±1.26mg/dl，基线、6、12、18 和 24 个月。PD 患者在 PD 后 6 个月时，不同分级 SUA 水平之间的全因死亡率存在显著差异（p=0.010），SUA 水平在 5.65mg/dl≤SUA<7.13mg/dl 级别的患者全因死亡率最低。
在随访期间，PD 后 SUA 水平下降。PD 后 6 个月时，5.65mg/dl≤SUA<7.13mg/dl 级别的 SUA 水平适合患者更好的生存。
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