一种锌伴侣介导一种无机商品流向一个重要的细胞客户。
A zinc chaperone mediates the flow of an inorganic commodity to an important cellular client.
机构信息
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Department of Microbiology and Molecular Genetics, Department of Chemistry, and Elemental Health Institute, Michigan State University, East Lansing, MI 48824, USA.
出版信息
Cell. 2022 Jun 9;185(12):2013-2015. doi: 10.1016/j.cell.2022.05.012.
Zinc is an essential element in living organisms, yet little is known about how cells ensure that zinc is allocated to the correct metalloproteins. Papers in Cell and Cell Reports demonstrate that the ZNG1 family of GTPases have metallochaperone functions: they directly transfer zinc to, and thereby activate, methionine aminopeptidases that are crucial for protein modification during or after translation.
锌是生物体必需的元素，但人们对细胞如何确保锌分配给正确的金属蛋白知之甚少。《细胞》和《细胞报告》上的论文表明，ZNG1 家族 GTPases 具有金属伴侣功能：它们直接将锌转移到并激活甲硫氨酸氨肽酶，而这些酶对于翻译过程中或翻译后蛋白质的修饰至关重要。
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