阿尔茨海默病中神经元的死亡：对神经炎症的影响。
How neurons die in Alzheimer's disease: Implications for neuroinflammation.
机构信息
Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA; Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, 22908, USA; Medical Scientist Training Program, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
出版信息
Curr Opin Neurobiol. 2022 Aug;75:102575. doi: 10.1016/j.conb.2022.102575. Epub 2022 Jun 10.
Despite the long-standing observation of vast neuronal loss in Alzheimer's disease (AD) our understanding of how and when neurons are eliminated is incomplete. While previous investigation has focused on apoptosis, several novel forms of cell death (i.e. necroptosis, parthanatos, ferroptosis, cuproptosis) have emerged that require further investigation. This review aims to collect evidence for different modes of neuronal cell death in AD and to also discuss how these different forms of cell death may impact the neuroinflammatory environment that prevails in the AD brain. Improved understanding of how neurons die may help to delineate disease pathogenesis, provide insights toward treatment, and aid in the development of improved animal models of AD.
尽管人们长期以来一直观察到阿尔茨海默病（AD）中大量神经元的丧失，但我们对神经元是如何以及何时被清除的仍不完全了解。虽然之前的研究集中在细胞凋亡上，但几种新的细胞死亡形式（即坏死性凋亡、细胞色素 c 凋亡、铁死亡、铜死亡）已经出现，需要进一步研究。本综述旨在收集 AD 中不同类型神经元细胞死亡的证据，并讨论这些不同形式的细胞死亡如何影响 AD 大脑中普遍存在的神经炎症环境。更好地了解神经元的死亡方式可能有助于描绘疾病的发病机制，为治疗提供见解，并有助于开发改进的 AD 动物模型。
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