Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Cognitive Fitness and Biopsychiatry Technology Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Int J Neurosci. 2024 Jun;134(1):16-27. doi: 10.1080/00207454.2022.2082966. Epub 2022 Jun 12.
The Montreal Cognitive Assessment (MoCA) rating scale is frequently used to assess cognitive impairments in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD).
The aims of this study were to a) evaluate the construct validity of the MoCA and its subdomains or whether the MoCA can be improved by feature reduction, and b) develop a short version of the MoCA (MoCA-Brief) for the Thai population.
We recruited 181 participants, namely 60 healthy controls, 61 aMCI, and 60 AD patients.
The construct reliability of the original MoCA was not optimal and could be improved by deleting one subdomain (Naming) and five items, namely Clock Circle, Lion, Digit Forward, Repeat 2nd Sentence, and Place, which showed inadequate loadings on their latent vectors. To construct the MoCA-Brief, the reduced model underwent further reduction and feature selection based on model quality data of the outer models. We produced a MoCA-Brief rating scale comprising five items, namely Clock Time, Subtract 7, Fluency, Month, and Year. The first latent vector extracted from these five indicators showed adequate construct validity with an Average Variance Extracted of 0.599, composite reliability of 0.822, Cronbach's alpha of 0.832 and rho A of 0.833. The MoCA-Brief factor score showed a strong correlation with the total MoCA score ( = 0.98, < 0.001) and shows adequate concurrent, test-retest, and inter-rater validity.
The construct validity of the MoCA may be improved by deleting five items. The new MoCA-Brief rating scale deserves validation in independent samples and especially in other countries.
蒙特利尔认知评估(MoCA)量表常用于评估遗忘型轻度认知障碍(aMCI)和阿尔茨海默病(AD)患者的认知障碍。
本研究旨在:a)评估 MoCA 及其子域的结构效度,或者通过特征减少是否可以改善 MoCA;b)为泰国人群开发 MoCA 的简短版本(MoCA-Brief)。
我们招募了 181 名参与者,包括 60 名健康对照者、61 名 aMCI 患者和 60 名 AD 患者。
原始 MoCA 的结构可靠性不是最佳的,可以通过删除一个子域(命名)和五个项目来提高,即时钟圆圈、狮子、数字向前、重复第二句话和地点,这些项目在其潜在向量上的负荷不足。为了构建 MoCA-Brief,简化模型基于外部模型的模型质量数据进行了进一步的简化和特征选择。我们产生了一个 MoCA-Brief 评分量表,包括五个项目,即时钟时间、减去 7、流畅性、月份和年份。从这五个指标中提取的第一个潜在向量显示出足够的结构效度,平均方差提取为 0.599,综合可靠性为 0.822,Cronbach's alpha 为 0.832,rho A 为 0.833。MoCA-Brief 因子得分与总 MoCA 得分呈强相关( = 0.98, < 0.001),具有足够的同时、重测和组内信度。
通过删除五个项目可以提高 MoCA 的结构效度。新的 MoCA-Brief 评分量表值得在独立样本中进行验证,特别是在其他国家。