中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）和单核细胞与白细胞比值（MWR）作为喉癌的诊断和预后标志物。
NLR, PLR, LMR and MWR as diagnostic and prognostic markers for laryngeal carcinoma.
作者信息
Li Pingdong, Li Haiyang, Ding Shuo, Zhou Jing
机构信息
Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University Beijing 100730, China.
Department of Otolaryngology, People's Hospital of Beijing Daxing District, Beijing 102600, China.
出版信息
Am J Transl Res. 2022 May 15;14(5):3017-3027. eCollection 2022.
OBJECTIVE
To evaluate whether neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and monocyte-to-white blood cell ratio (MWR) can be used as diagnostic and prognostic markers for laryngeal carcinoma (LC).
METHODS
In this retrospective study, 50 patients with LC treated in the Department of Otolaryngology, Head and Neck Surgery of Beijing Tongren Hospital from August 2014 to August 2015 were enrolled in research group. In addition, 40 healthy volunteers from the same period were selected as control group. The counts of white blood cells, neutrophils, lymphocytes, monocytes and platelets in the peripheral blood of participants were measured with a blood counting instrument (Sysmex XE-2100, Sysmex Corporation, Japan), and the NLR, PLR, LMR and MWR were calculated. After that, the survival rate of patients was observed through a 5-year follow-up. The prognostic value of the above four indexes and their combination was discussed in patients with different clinical characteristics.
RESULTS
Compared with the control group, the NLR, PLR and MWR were higher and the LMR was lower in the research group. In terms of survival, patients with higher NLR, PLR and MWR and lower LMR showed a higher 5-year mortality than those with lower NLR, PLR and MWR and higher LMR, indicating that NLR, PLR and MWR were higher and LMR was lower in the survival group than in the death group. Subsequent analysis identified that NLR, PLR, LMR and MWR were closely correlated with age, alcohol drinking, smoking, clinical staging and T-staging. Clinical staging, T-staging, NLR, PLR, LMR, and MWR were confirmed as influencing factors for LC.
CONCLUSIONS
NLR, PLR, LMR, and MWR can be used as diagnostic and prognostic markers for LC and their combination has a superior diagnostic performance.
目的
评估中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）及单核细胞与白细胞比值（MWR）能否作为喉癌（LC）的诊断及预后标志物。
方法
在这项回顾性研究中，选取2014年8月至2015年8月在北京同仁医院耳鼻咽喉头颈外科接受治疗的50例LC患者作为研究组。此外，选取同期40名健康志愿者作为对照组。采用血液计数仪（Sysmex XE - 2100，日本Sysmex公司）检测参与者外周血中的白细胞、中性粒细胞、淋巴细胞、单核细胞及血小板计数，并计算NLR、PLR、LMR和MWR。之后，通过5年随访观察患者的生存率。探讨上述四项指标及其组合在不同临床特征患者中的预后价值。
结果
与对照组相比，研究组的NLR、PLR和MWR较高，而LMR较低。在生存率方面，NLR、PLR和MWR较高且LMR较低的患者5年死亡率高于NLR、PLR和MWR较低且LMR较高的患者，表明生存组的NLR、PLR和MWR较高，而LMR低于死亡组。后续分析发现，NLR、PLR、LMR和MWR与年龄、饮酒、吸烟、临床分期及T分期密切相关。临床分期、T分期、NLR、PLR、LMR和MWR被确认为LC的影响因素。
结论
NLR、PLR、LMR和MWR可作为LC的诊断及预后标志物，且它们的组合具有更优的诊断性能。
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