血清白细胞介素-6作为间质性肾炎疾病进展的标志物。
Serum IL-6 as a marker of disease progression in interstitial nephritis.
作者信息
Shen Wei, Bian Luyan, Ma Ying, Yin Xiuyan
机构信息
People's Hospital of Rizhao Rizhao, Shandong, China.
Department of Nephrology, Qingdao Municipal Hospital Qingdao, Shandong, China.
出版信息
Am J Transl Res. 2022 May 15;14(5):3189-3197. eCollection 2022.
OBJECTIVE
To investigate the mechanism of serum interleukin-6 (IL-6) change in disease progression of interstitial nephritis.
METHODS
This is a retrospective study. From November 2017 to November 2019, 87 patients with interstitial nephritis treated in our hospital were enrolled and divided into an acute group (n=42) and a chronic group (n=45) based on pathological results of renal biopsies. Forty healthy individuals after physical examination during the same period were enrolled into the reference group. Serum IL-6 levels were determined using the enzyme-linked immunosorbent assay (ELISA).
RESULTS
Among the three groups, patients in the acute group showed the highest IL-6 level (P<0.001). The acute group obtained higher serum advanced oxidation protein products (AOPP) levels and glomerular filtration rate (GFR) than the other two groups (P<0.05). The acute group showed lower levels of CD34 [number of positive microvessels (MVs)/HP], a smaller type III collagen positive area, and a larger type IV collagen positive area than the chronic group (P<0.05). The acute group obtained higher levels of IL-27 and tumor necrosis factor-α (TNF-α) than the chronic group (P<0.001). The acute group had higher levels of serum creatinine (SCr), erythrocyte sedimentation rate (ESR), estimated glomerular filtration rate (eGFR), and 24-hour urine protein quantity (24 h UPQ) than the other groups (P<0.001). The combined detection of serum IL-6, TNF-α, and micro-albumin (mALB) outperformed the stand-alone approach (P<0.05). Serum IL-32 and kidney injury molecule-1 (KIM-1) levels in the acute and chronic group were positively correlated with SCr and 24 h UPQ (P<0.05).
CONCLUSIONS
Serum IL-6 shows a great potential as an important marker of disease progression in interstitial nephritis.
目的
探讨血清白细胞介素-6（IL-6）在间质性肾炎疾病进展中的变化机制。
方法
本研究为回顾性研究。2017年11月至2019年11月，选取我院收治的87例间质性肾炎患者，根据肾活检病理结果分为急性组（n = 42）和慢性组（n = 45）。同期选取40例体检健康者作为参照组。采用酶联免疫吸附测定（ELISA）法检测血清IL-6水平。
结果
三组中，急性组患者的IL-6水平最高（P < 0.001）。急性组血清晚期氧化蛋白产物（AOPP）水平和肾小球滤过率（GFR）高于其他两组（P < 0.05）。急性组的CD34水平[微血管（MV）阳性数/HP]低于慢性组，III型胶原阳性面积小于慢性组，IV型胶原阳性面积大于慢性组（P < 0.05）。急性组的IL-27和肿瘤坏死因子-α（TNF-α）水平高于慢性组（P < 0.001）。急性组的血清肌酐（SCr）、红细胞沉降率（ESR）、估算肾小球滤过率（eGFR）和24小时尿蛋白量（24 h UPQ）高于其他组（P < 0.001）。血清IL-6、TNF-α和微量白蛋白（mALB）联合检测优于单独检测（P < 0.05）。急性组和慢性组血清IL-32和肾损伤分子-1（KIM-1）水平与SCr和24 h UPQ呈正相关（P < 0.05）。
结论
血清IL-6作为间质性肾炎疾病进展的重要标志物具有很大潜力。
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