塞尔维诺霉素的结构，一种对厌氧菌和支原体有效的新型呫吨酮抗生素。

Structure of cervinomycin, a novel xantone antibiotic active against anaerobe and mycoplasma.

作者信息

Nakagawa A, Omura S, Kushida K, Shimizu H, Lukacs G

出版信息

J Antibiot (Tokyo). 1987 Mar;40(3):301-8. doi: 10.7164/antibiotics.40.301.

DOI:10.7164/antibiotics.40.301

Abstract

The structures of cervinomycins A1 (1) and A2 (2), a potent anti-anaerobic and anti-mycoplasmal antibiotic were investigated by means of recent NMR techniques of O-methyl ether (3) and C,O-dimethyl ether (4) obtained by methylation of 2 with CH3I in the presence of Ag2O. The antibiotic 2 posesses a polycyclic structure involving a xanthone skeleton. The structure of 1 was confirmed to be a hydroquinone of 2 from the evidences that oxidation of 1 with Ag2O and acetylation of 1 with (CH3CO)2O in pyridine afforded quantitatively 2 and triacetylcervinomycin A1 (7), respectively.

摘要

利用最近的核磁共振技术，对具有强大抗厌氧菌和抗支原体活性的抗生素鹿霉素A1（1）和A2（2）的结构进行了研究。通过在氧化银存在下用碘甲烷对2进行甲基化得到了O - 甲基醚（3）和C，O - 二甲基醚（4）。抗生素2具有包含呫吨酮骨架的多环结构。根据以下证据证实1的结构是2的对苯二酚：用氧化银氧化1以及在吡啶中用乙酸酐乙酰化1分别定量得到2和三乙酰鹿霉素A1（7）。