Centre for Medical Radiation Physics, School of Physics, University of Wollongong, Wollongong, New South Wales, Australia.
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
J Appl Clin Med Phys. 2022 Sep;23(9):e13665. doi: 10.1002/acm2.13665. Epub 2022 Jun 17.
Recently the use of linear accelerator (linac)-based stereotactic radiosurgery (SRS) has increased, including single-isocenter multiple-target SRS. The workload of medical physicists has grown as a result and so has the necessity of maximizing the efficiency of quality assurance (QA). This study aimed to determine if measurement-based patient-specific QA with a high-spatial-resolution dosimeter is sensitive to rotational errors, potentially reducing the need for routine off-axis Winston-Lutz (WL) testing.
The impact of rotational errors along gantry, couch, and collimator axes on dose coverage of the gross tumor volume (GTV) and planning target volume (PTV) was determined with a 1-mm GTV/PTV expansion margin. Two techniques, the off-axis WL test using the StereoPHAN MultiMet-WL Cube (Sun Nuclear Corporation, Melbourne, Florida, USA) and patient-specific QA using the SRS MapCHECK (Sun Nuclear Corporation, Melbourne, Florida, USA), were assessed on their ability to detect introduced errors before target coverage was compromised. These findings were also considered in the context of routine machine QA of rotational axis calibrations.
Rotational errors significantly impacted PTV dose coverage, especially in the couch angle. GTV dose coverage remained unaffected except for with large couch angle errors (≥1.5°). The off-axis WL test was shown to be sensitive to rotational errors with results consistently exceeding tolerance levels when or before coverage fell below departmentally accepted limits. Although patient-specific QA using the SRS MapCHECK was previously validated for SRS, this study showed inconsistency in detection of rotational errors.
It is recommended that off-axis WL testing be conducted regularly to supplement routine monthly machine QA, as it is sensitive to errors that patient-specific QA may not detect. This frequency should be determined by individual departments, with consideration of GTV-PTV margins used, limitations on target off-axis distances, and routine mechanical QA results for particular linacs.
最近,基于线性加速器(linac)的立体定向放射外科(SRS)的应用有所增加,包括单中心点多靶 SRS。因此,医学物理学家的工作量增加了,同时也需要最大限度地提高质量保证(QA)的效率。本研究旨在确定是否可以使用高空间分辨率剂量仪进行基于测量的患者特异性 QA,以检测旋转误差,从而可能减少对常规轴外 Winston-Lutz(WL)测试的需求。
通过 1mm 的 GTV/PTV 扩展边界,确定在机架、治疗床和准直器轴上的旋转误差对大体肿瘤体积(GTV)和计划靶区(PTV)剂量覆盖的影响。评估了两种技术,即使用 StereoPHAN MultiMet-WL Cube(Sun Nuclear Corporation,佛罗里达州墨尔本,美国)的轴外 WL 测试和使用 SRS MapCHECK(Sun Nuclear Corporation,佛罗里达州墨尔本,美国)的患者特异性 QA,以确定它们在靶区覆盖受到影响之前检测引入误差的能力。还根据旋转轴校准的常规机器 QA 考虑了这些发现。
旋转误差显著影响 PTV 剂量覆盖,尤其是在治疗床角度上。除了较大的治疗床角度误差(≥1.5°)外,GTV 剂量覆盖不受影响。轴外 WL 测试对旋转误差敏感,当或在覆盖范围低于部门接受的限制之前,结果始终超过公差水平。尽管之前已经验证了使用 SRS MapCHECK 的患者特异性 QA 用于 SRS,但本研究显示其对旋转误差的检测不一致。
建议定期进行轴外 WL 测试,以补充常规的每月机器 QA,因为它对患者特异性 QA 可能无法检测到的误差敏感。这种频率应由各个部门确定,考虑使用的 GTV-PTV 边界、靶区轴外距离的限制以及特定直线加速器的常规机械 QA 结果。