Clinical Microbiology, Virology and Bioemergency Diagnostics, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy.
Department of Biomedical and Clinical Sciences, Università Degli Studi di Milano, Italy; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy.
Travel Med Infect Dis. 2022 Sep-Oct;49:102386. doi: 10.1016/j.tmaid.2022.102386. Epub 2022 Jun 20.
Human monkeypox (MPX) is a neglected zoonotic disease caused by the MPX virus a double-stranded DNA virus which belongs to the Poxviridae family genus Orthopoxvirus. It is endemic in the rural rainforests of Central and Western Africa where it is responsible of human sporadic cases and outbreaks since 1970. Outside Africa MPXV caused an outbreak in 2003 in the United States linked to importation of infected rodents from Ghana and a few travel-related cases in the USA, United Kingdom, Israel and Singapore. Actually, a worldwide outbreak with more than 1200 confirmed cases mainly concentrated among men who have sex with men is ongoing.
We present the case of an Italian man living in Portugal that was diagnosed with MPX at our clinic in Milan, Italy. Monkeypox virus infection was confirmed by a specific homemade Real-Time PCR. Samples obtained from different sites (pharynx, skin lesions, anal ulcer, seminal fluid) turned all positive with different viral load.
Our report illustrates the challenge of a disease that seems to present in a different way from classic description with possible human-to-human transmission through sexual contact.
人类猴痘（MPX）是一种被忽视的人畜共患疾病，由猴痘病毒引起，该病毒是一种双链 DNA 病毒，属于痘病毒科正痘病毒属。它在中非和西非的农村雨林中流行，自 1970 年以来，该病毒导致了人类的散发病例和暴发。在非洲以外，2003 年，美国因从加纳进口受感染的啮齿动物以及美国、英国、以色列和新加坡的几例与旅行相关的病例而爆发了猴痘。实际上，目前正在全球范围内爆发，已有超过 1200 例确诊病例，主要集中在男男性行为者中。
我们报告了一名居住在葡萄牙的意大利男子的病例，他在意大利米兰的诊所被诊断患有猴痘。猴痘病毒感染通过特定的国产实时 PCR 得到确认。从不同部位（咽部、皮肤损伤、肛门溃疡、精液）获得的样本均呈阳性，病毒载量不同。
我们的报告说明了一种疾病的挑战，这种疾病似乎与经典描述的方式不同，可能通过性接触在人与人之间传播。
