产 KPC-3 和 NDM-1 的肺炎克雷伯菌 ST307 的出现和克隆扩张。
Emergence and clonal expansion of Klebsiella pneumoniae ST307, simultaneously producing KPC-3 and NDM-1.
机构信息
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Instituto de Investigaciones en Bacteriología y Virología Molecular (IBaViM), Ciudad Autónoma de Buenos Aires, Argentina; CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), Ciudad Autónoma de Buenos Aires, Argentina.
Hospital Donación Francisco Santojanni, Ciudad Autónoma de Buenos Aires, Argentina.
出版信息
Rev Argent Microbiol. 2022 Oct-Dec;54(4):288-292. doi: 10.1016/j.ram.2022.04.002. Epub 2022 Jun 24.
MDR Klebsiella pneumoniae ST307 is a high-risk clone, whose genetic features contribute to its adaptation to hospital environments and the human host. This study describes the emergence and clonal dissemination of K. pneumoniae ST307, recovered during November 2018 to February 2019 in a hospital in Buenos Aires city, which concurrently harbored KPC-3 and NDM-1. These isolates were resistant to all β-lactams and to the ceftazidime/avibactam combination. Molecular studies showed that bla was located in Tn4401a platform, while bla was surrounded upstream by ISKpn14 followed by a partial sequence of ISAba125 and downstream by bleMBL-trpF, located in a 145.5kb conjugative plasmid belonging to the Inc A/C group. The dissemination of K. pneumoniae ST307 isolates co-producing KPC-3 and NDM-1 could lead to a worrisome scenario due to the remarkable features of this clone and its resistance profile.
产碳青霉烯酶肺炎克雷伯菌 ST307 是一种高危克隆，其遗传特征有助于其适应医院环境和人体宿主。本研究描述了 2018 年 11 月至 2019 年 2 月期间在布宜诺斯艾利斯市一家医院中分离到的产 KPC-3 和 NDM-1 的肺炎克雷伯菌 ST307 的出现和克隆传播。这些分离株对所有β-内酰胺类药物和头孢他啶/阿维巴坦联合用药均具有耐药性。分子研究表明，bla 位于 Tn4401a 平台上，而 bla 上游被 ISKpn14 包围，其后是 ISAba125 的部分序列，下游是 bleMBL-trpF，位于一个属于 Inc A/C 组的 145.5kb 可接合质粒中。同时产 KPC-3 和 NDM-1 的肺炎克雷伯菌 ST307 分离株的传播可能会导致令人担忧的情况，因为该克隆具有显著特征及其耐药谱。
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