COVID-19 住院后生活质量和持续症状。一项比较 ICU 与非 ICU 患者的前瞻性观察研究。
Quality of life and persistent symptoms after hospitalization for COVID-19. A prospective observational study comparing ICU with non-ICU patients.
机构信息
Servicio de Anestesiología y Reanimación, Hospital Clínico Universitario de Santiago de Compostela, Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, Spain.
Servicio de Neumología, Hospital Clínico Universitario de Santiago de Compostela, Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, Spain.
出版信息
Rev Esp Anestesiol Reanim (Engl Ed). 2022 Jun-Jul;69(6):326-335. doi: 10.1016/j.redare.2022.06.002. Epub 2022 Jun 10.
BACKGROUND
Hospitalized COVID-19 patients are prone to develop persistent symptoms and to show reduced quality of life following hospital admission.
METHODS
Prospective cohort study of COVID-19 patients admitted to a hospital from March 1 to April 30, 2020. The primary outcome was to compare health related quality of life and persistent symptoms six months after hospital admission, of COVID-19 patients who required ICU admission with those who did not.
RESULTS
Among the 242 patients hospitalized during the defined period of time, 44 (18.2%) needed ICU admission. Forty (16.5%) patients died during hospital admission. Two hundred and two (83.5%) patients were discharged alive from the hospital. At six months, 183 (75.6%) patients completed the questionnaires (32 ICU patients and 151 non ICU patients). Ninety-six (52.4%) reported decreased quality of life and 143 (78.1%) described persistent symptoms. More ICU patients showed worsening of their quality of life (71.9% vs 43.7%, P=0.004). There were no differences in the proportion of patients with persistent symptoms between ICU and non ICU patients (87.5% vs 76.2%, P=0.159). ICU patients showed more frequently dyspnea on exertion (78.1% vs 47.7%, P=0.02), dyspnea on light exertion (37.5% vs 4.6%, P<0.001), and asthenia (56.3 vs 29.1, P=0.003).
CONCLUSIONS
Survivors of COVID-19 needing hospitalization had persistent symptoms and a decline in the quality of life. ICU patients referred a large decrease of their quality of life compared with non ICU patients.
背景
住院的 COVID-19 患者在入院后容易出现持续症状，并降低生活质量。
方法
对 2020 年 3 月 1 日至 4 月 30 日期间因 COVID-19 住院的患者进行前瞻性队列研究。主要结局是比较需要 ICU 入院和不需要 ICU 入院的 COVID-19 患者在入院后 6 个月时的健康相关生活质量和持续症状。
结果
在所定义的时间段内住院的 242 名患者中，有 44 名（18.2%）需要 ICU 入院。40 名（16.5%）患者在住院期间死亡。202 名（83.5%）患者从医院出院存活。6 个月时，183 名（75.6%）患者完成了问卷调查（32 名 ICU 患者和 151 名非 ICU 患者）。96 名（52.4%）报告生活质量下降，143 名（78.1%）描述存在持续症状。更多的 ICU 患者生活质量恶化（71.9%比 43.7%，P=0.004）。ICU 患者和非 ICU 患者之间持续症状的患者比例没有差异（87.5%比 76.2%，P=0.159）。ICU 患者更常出现活动时呼吸困难（78.1%比 47.7%，P=0.02）、轻度活动时呼吸困难（37.5%比 4.6%，P<0.001）和乏力（56.3%比 29.1%，P=0.003）。
结论
需要住院治疗的 COVID-19 幸存者存在持续症状和生活质量下降。与非 ICU 患者相比，需要 ICU 治疗的 COVID-19 患者的生活质量大幅下降。
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