丹麦无家可归者和收容所工作人员中 SARS-CoV-2 抗体流行率：一项全国性横断面研究。
SARS-CoV-2 antibody prevalence among homeless people and shelter workers in Denmark: a nationwide cross-sectional study.
机构信息
Department of Cardiology, Copenhagen University Hospital, Herlev and Gentofte, Borgmester Ib Juuls Vej 1, 2730, Herlev, Denmark.
Department of Emergency Medicine, Copenhagen University Hospital, Herlev and Gentofte, Herlev, Denmark.
出版信息
BMC Public Health. 2022 Jun 27;22(1):1261. doi: 10.1186/s12889-022-13642-7.
BACKGROUND
People experiencing homelessness (PEH) and associated shelter workers may be at higher risk of infection with "Severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2). The aim of this study was to determine the prevalence of SARS-CoV-2 among PEH and shelter workers in Denmark.
DESIGN AND METHODS
In November 2020, we conducted a nationwide cross-sectional seroprevalence study among PEH and shelter workers at 21 recruitment sites in Denmark. The assessment included a point-of-care test for antibodies against SARS-CoV-2, followed by a questionnaire. The seroprevalence was compared to that of geographically matched blood donors considered as a proxy for the background population, tested using a total Ig ELISA assay.
RESULTS
We included 827 participants in the study, of whom 819 provided their SARS-CoV-2 antibody results. Of those, 628 were PEH (median age 50.8 (IQR 40.9-59.1) years, 35.5% female) and 191 were shelter workers (median age 46.6 (IQR 36.1-55.0) years and 74.5% female). The overall seroprevalence was 6.7% and was similar among PEH and shelter workers (6.8% vs 6.3%, p = 0.87); and 12.2% among all participants who engaged in sex work. The overall participant seroprevalence was significantly higher than that of the background population (2.9%, p < 0.001). When combining all participants who reported sex work or were recruited at designated safe havens, we found a significantly increased risk of seropositivity compared to other participants (OR 2.23, 95%CI 1.06-4.43, p = 0.02). Seropositive and seronegative participants reported a similar presence of at least one SARS-CoV-2 associated symptom (49% and 54%, respectively).
INTERPRETATIONS
The prevalence of SARS-CoV-2 antibodies was more than twice as high among PEH and associated shelter workers, compared to the background population. These results could be taken into consideration when deciding in which phase PEH are eligible for a vaccine, as part of the Danish national SARS-CoV-2 vaccination program rollout.
FUNDING
TrygFonden and HelseFonden.
背景
无家可归者（PEH）和相关庇护所工作人员可能面临更高的感染“严重急性呼吸综合征冠状病毒 2”（SARS-CoV-2）的风险。本研究旨在确定丹麦 PEH 和庇护所工作人员中 SARS-CoV-2 的流行率。
设计和方法
2020 年 11 月，我们在丹麦 21 个招募点对 PEH 和庇护所工作人员进行了一项全国性的横断面血清流行率研究。评估包括针对 SARS-CoV-2 抗体的即时护理检测，随后进行问卷调查。血清流行率与地理匹配的血液供体进行比较，血液供体被视为背景人群的代表，使用总 Ig ELISA 检测。
结果
我们共纳入了 827 名参与者，其中 819 名提供了 SARS-CoV-2 抗体结果。其中，628 名为 PEH（中位年龄 50.8（IQR 40.9-59.1）岁，35.5%为女性），191 名为庇护所工作人员（中位年龄 46.6（IQR 36.1-55.0）岁，74.5%为女性）。总血清流行率为 6.7%，在 PEH 和庇护所工作人员中相似（6.8%与 6.3%，p=0.87）；所有从事性工作者的血清流行率为 12.2%。所有参与者的总体血清流行率明显高于背景人群（2.9%，p<0.001）。当将所有报告有性工作或在指定安全避难所招募的参与者合并时，与其他参与者相比，血清阳性的风险显著增加（OR 2.23，95%CI 1.06-4.43，p=0.02）。血清阳性和血清阴性参与者报告的至少有一种 SARS-CoV-2 相关症状的存在情况相似（分别为 49%和 54%）。
解释
与背景人群相比，PEH 和相关庇护所工作人员的 SARS-CoV-2 抗体流行率高出两倍多。这些结果在决定 PEH 何时有资格接种疫苗时可以作为丹麦国家 SARS-CoV-2 疫苗接种计划推出的一部分考虑。
资助
TrygFonden 和 HelseFonden。
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