生物启发的氧化铜纳米颗粒的探索：合成、表征及体外生物学研究

The exploration of bio-inspired copper oxide nanoparticles: synthesis, characterization and in-vitro biological investigations.

作者信息

Kolahalam Lalitha Ammadu, Prasad K R S, Krishna P Murali, Supraja N, Shanmugan S

机构信息

Department of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, 522502, Andhra Pradesh, India.

Department of Chemistry, Ramaiah Institute of Technology (Autonomous Institute, Affiliated to VTU), Bangalore, 560054, Karnataka, India.

出版信息

Heliyon. 2022 Jun 11;8(6):e09726. doi: 10.1016/j.heliyon.2022.e09726. eCollection 2022 Jun.

The paper describes the synthesis and characterization of copper oxide nanoparticles (CuO NPs) using the mixture of plant rhizome extracts and as a reducing agent. The prepared CuO nanoparticles are characterized and confirmed their formation based on data obtained from powder X-ray diffraction spectroscopy, Fourier Transmission Infrared, Ultraviolet-Visible spectra, Field Emission Scanning Electron Microscopy images, Energy Dispersive X-ray analysis and Dynamic light scattering techniques and data reveal that the average size of CuO Nps was 103.4 nm. The result of antibacterial and antifungal activities for concentrations 50, 100, and 170 ppm indicate that NPs may exhibit appreciable activity at higher (170 ppm) concentrations. The MTT cytotoxic assay studies of Chinese Hamster Ovary (CHO) cell lines showed a Half-maximal inhibitory concentration (IC) value of 4.14 μg/mL.

该论文描述了使用植物根茎提取物混合物作为还原剂合成和表征氧化铜纳米颗粒（CuO NPs）的过程。基于粉末X射线衍射光谱、傅里叶透射红外光谱、紫外可见光谱、场发射扫描电子显微镜图像、能量色散X射线分析和动态光散射技术获得的数据，对制备的CuO纳米颗粒进行了表征并确认了其形成，数据显示CuO纳米颗粒的平均尺寸为103.4纳米。浓度为50、100和170 ppm时的抗菌和抗真菌活性结果表明，纳米颗粒在较高浓度（170 ppm）下可能表现出明显的活性。中国仓鼠卵巢（CHO）细胞系的MTT细胞毒性试验研究显示，半数抑制浓度（IC）值为4.14 μg/mL。