Saha Santosh Kumar, Choudhury Kamrun Nahar, Zareen Salma, Mousum Sabrina, Mamun Mohammad Abdullah Al, Haque M Atiqul
National Institute of Cardiovascular Diseases and Hospital, Dhaka, Bangladesh.
National Center for Control of Rheumatic Fever and Heart Disease, Dhaka, Bangladesh.
SAGE Open Med. 2022 Jun 28;10:20503121221108558. doi: 10.1177/20503121221108558. eCollection 2022.
The standard reference value of anti-streptolysin O (ASO) titre for diagnosing acute rheumatic fever (RF) in children is yet to be determined in Bangladesh. We aimed to measure the upper limit of the normal (ULN) of ASO titre among healthy children to determine the cut-off value for the diagnosis of RF in Bangladesh.
A total of 400 healthy children aged 5-15 years with no history of fever, sore throat and impetigo during the last 8 weeks of the study were enrolled. The respondents were randomly selected from an urban non-slum area, an urban slum area and a rural area of Bangladesh. ASO titre was measured using a turbidimetric immunoassay based on the principle of an agglutination reaction. The 80th percentile value was considered as the ULN of ASO titre.
Approximately 55% of the children were male. The mean (SD) age of children was 9.1 (2.7) years. The ULN of ASO titre for 5-15 years aged children was 217.4 IU/mL.
Our reference value of ASO titre at the 80th percentile will be an essential guide for clinicians to diagnose acute RF.
在孟加拉国，用于诊断儿童急性风湿热（RF）的抗链球菌溶血素O（ASO）滴度的标准参考值尚未确定。我们旨在测量健康儿童中ASO滴度的正常上限（ULN），以确定孟加拉国诊断RF的临界值。
共纳入400名5 - 15岁的健康儿童，这些儿童在研究的最后8周内无发热、咽痛和脓疱病病史。研究对象从孟加拉国的一个城市非贫民窟地区、一个城市贫民窟地区和一个农村地区随机选取。基于凝集反应原理，采用比浊免疫测定法测量ASO滴度。第80百分位数被视为ASO滴度的ULN。
约55%的儿童为男性。儿童的平均（标准差）年龄为9.1（2.7）岁。5 - 15岁儿童的ASO滴度ULN为217.4 IU/mL。
我们第80百分位数的ASO滴度参考值将为临床医生诊断急性RF提供重要指导。
