Department of Nutrition and Toxicology, School of Public Health, State Key Laboratory of Experimental Hematology, Hangzhou Normal University, Hangzhou, China.
The Fourth Affiliated Hospital, The First Affiliated Hospital, Institute of Translational Medicine, School of Public Health, Cancer Center, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou, China.
Nat Rev Cardiol. 2023 Jan;20(1):7-23. doi: 10.1038/s41569-022-00735-4. Epub 2022 Jul 4.
The maintenance of iron homeostasis is essential for proper cardiac function. A growing body of evidence suggests that iron imbalance is the common denominator in many subtypes of cardiovascular disease. In the past 10 years, ferroptosis, an iron-dependent form of regulated cell death, has become increasingly recognized as an important process that mediates the pathogenesis and progression of numerous cardiovascular diseases, including atherosclerosis, drug-induced heart failure, myocardial ischaemia-reperfusion injury, sepsis-induced cardiomyopathy, arrhythmia and diabetic cardiomyopathy. Therefore, a thorough understanding of the mechanisms involved in the regulation of iron metabolism and ferroptosis in cardiomyocytes might lead to improvements in disease management. In this Review, we summarize the relationship between the metabolic and molecular pathways of iron signalling and ferroptosis in the context of cardiovascular disease. We also discuss the potential targets of ferroptosis in the treatment of cardiovascular disease and describe the current limitations and future directions of these novel treatment targets.
铁稳态的维持对于心脏功能的正常运作至关重要。越来越多的证据表明，铁失衡是许多心血管疾病亚型的共同特征。在过去的 10 年中，铁死亡作为一种依赖铁的细胞死亡形式，已逐渐被认为是介导多种心血管疾病发病机制和进展的重要过程，包括动脉粥样硬化、药物诱导性心力衰竭、心肌缺血再灌注损伤、脓毒症诱导性心肌病、心律失常和糖尿病性心肌病。因此，深入了解调节心肌细胞中铁代谢和铁死亡的机制可能会改善疾病的管理。在这篇综述中，我们总结了铁信号转导的代谢和分子途径与心血管疾病中铁死亡之间的关系。我们还讨论了铁死亡在心血管疾病治疗中的潜在靶点，并描述了这些新的治疗靶点的当前局限性和未来方向。
