肝移植术后急性移植物抗宿主病：病例报告及当前文献综述
Acute Graft Versus Host Disease Following Liver Transplantation: Case Report With Review of Current Literature.
作者信息
Renganathan Kirubakaran K, Ramamurthy Anand, Jacob Sheeba, Tharigopula Anil, Vaidya Anil, Gopashetty Mahesh, Khakar Anand
机构信息
Consultant Hepatobiliary, Pancreatic Surgery and Liver Transplantation, PSG Institute of Medical Sciences and Research, Peelamedu Coimbatore, India.
Senior Consultant, Surgical Gastroenterology and Liver Transplantation, Hindu Mission Hospital, 103 GST Road, Tambaram, Chennai 600045, India.
出版信息
J Clin Exp Hepatol. 2022 Jul-Aug;12(4):1244-1251. doi: 10.1016/j.jceh.2022.03.009. Epub 2022 Apr 1.
Abstract
Graft verus host disease (GVHD) following Liver transplantation is rare life threatening complication with very high mortality rate around 85%. Due to increased recognition of this condition management approach is rapidly evolving due to newer diagnostic methods and drugs. Etiology, risk factors, pathogenesis, preventive strategies, management approach and newer drugs are discussed. We present our experience of 2 cases from a large cohort of 1052 Liver transplant operations over a decade.
摘要
肝移植后发生的移植物抗宿主病（GVHD）是一种罕见但危及生命的并发症，死亡率极高，约为85%。由于对这种疾病的认识不断提高，加上新的诊断方法和药物的出现，其管理方法正在迅速发展。本文讨论了其病因、危险因素、发病机制、预防策略、管理方法及新药。我们介绍了在十年间1052例肝移植手术的大样本队列中2例患者的治疗经验。
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