Department of Otolaryngology - Head & Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA.
Ann Otol Rhinol Laryngol. 2023 Jun;132(6):667-673. doi: 10.1177/00034894221112501. Epub 2022 Jul 14.
To determine if there is a recovery time difference between patients with and without obstructive sleep apnea (OSA) when using total intravenous anesthesia (TIVA) compared to volatile gas inhalational anesthesia.
OSA and Non-OSA patients were identified at a tertiary institution between January 2019 and November 2020. Non-OSA patients were defined as those who have not been formerly diagnosed with OSA. A modified STOP-BANG score (MSBS) was performed to screen Non-OSA patients for OSA. Recovery was measured by Phase I recovery time, or time it took a patient to reach ≥9/10 on the Aldrete scoring system.
A total of 334 patients were included with 142 in the OSA cohort (59 TIVA, 83 inhalational anesthesia) and 192 in the Non-OSA cohort (119 TIVA, 73 inhalational anesthesia). In OSA patients, there was a 41.29-minute recovery time reduction when using TIVA versus sevoflurane ( < .0001). Non-OSA patients recovered faster than OSA patients when undergoing inhalational anesthesia by 46.76 minutes and TIVA by 18.58 minutes ( < .0001 and = .0907, respectively). Non-OSA patients with a MSBS < 3 and ≥3 had a shorter recovery time compared to OSA patients when both underwent sevoflurane anesthesia (57.27 minutes, < .0001 and 56.23 minutes, = .040, respectively). Non-OSA patients with a MSBS of <3 had a decrease in recovery time of 26.68 minutes when compared to OSA patients who underwent TIVA ( = .0004).
When utilizing TIVA over inhalational anesthesia, patients with OSA have significantly increased benefit in terms of reduced Phase I recovery times as compared to Non-OSA patients.
本研究旨在比较全凭静脉麻醉(TIVA)与挥发性吸入麻醉在患有和不患有阻塞性睡眠呼吸暂停(OSA)的患者中的恢复时间差异。
在 2019 年 1 月至 2020 年 11 月期间,我们在一家三级医疗机构中确定了 OSA 和非 OSA 患者。非 OSA 患者定义为未被诊断为 OSA 的患者。采用改良 STOP-BANG 评分(MSBS)筛查非 OSA 患者是否患有 OSA。通过第一阶段恢复时间(即患者达到 Aldrete 评分系统≥9/10 的时间)来衡量恢复情况。
共纳入 334 例患者,其中 OSA 组 142 例(59 例接受 TIVA,83 例接受吸入麻醉),非 OSA 组 192 例(119 例接受 TIVA,73 例接受吸入麻醉)。在 OSA 患者中,与使用七氟醚相比,TIVA 可将恢复时间缩短 41.29 分钟( < .0001)。非 OSA 患者在接受吸入麻醉时比 OSA 患者恢复更快,分别快 46.76 分钟和 18.58 分钟( < .0001 和 = .0907)。MSBS<3 和≥3 的非 OSA 患者在接受七氟醚麻醉时,与 OSA 患者相比,恢复时间更短(57.27 分钟, < .0001 和 56.23 分钟, = .040)。与接受 TIVA 的 OSA 患者相比,MSBS<3 的非 OSA 患者的恢复时间减少了 26.68 分钟( = .0004)。
与非 OSA 患者相比,OSA 患者在使用 TIVA 时,第一阶段恢复时间明显缩短,获益更大。