Shabana A H, el-Labban N G, Lee K W
J Clin Pathol. 1987 Apr;40(4):454-8. doi: 10.1136/jcp.40.4.454.
The size and shape of the cells in the basal cell layer of the oral epithelium in 100 specimens from oral mucosa were studied by using an interactive image analysis system (IBAS-1). Four groups of white lesions (traumatic keratosis, lichen planus, leucoplakia, and a "risk group") in addition to two control groups (normal mucosa and squamous cell carcinoma) were studied retrospectively. The results showed a progressive increase in the dimensions (area, perimeter, and maximum diameter) of the nuclei from normal mucosa through traumatic keratosis, lichen planus, leucoplakia and the "risk group" to carcinoma, with considerable differences. The nucleus in squamous cell carcinoma was twice as large as in normal mucosa. A substantial increase in the dimensions of both the cell and the nucleus was found in the "risk group." The nucleo:cytoplasmic ratio, contrary to what might have been anticipated in risk lesions, did not show considerable differences between the diagnostic groups. Furthermore, it was slightly decreased in the risk group compared with the normal mucosa. The shape factors (form PE and contour index) seemed to be less helpful in the identification of the "risk group." The size of the basal cell and its nucleus can be of diagnostic value for lesions with a high risk of malignant transformation.
利用交互式图像分析系统（IBAS-1）对取自口腔黏膜的100份标本中口腔上皮基底细胞层细胞的大小和形态进行了研究。除两组对照组（正常黏膜和鳞状细胞癌）外，还对四组白色病变（创伤性角化病、扁平苔藓、白斑和一个“风险组”）进行了回顾性研究。结果显示，从正常黏膜到创伤性角化病、扁平苔藓、白斑、“风险组”再到癌，细胞核的尺寸（面积、周长和最大直径）逐渐增大，且差异显著。鳞状细胞癌中的细胞核大小是正常黏膜中的两倍。在“风险组”中发现细胞和细胞核的尺寸均大幅增加。核质比与风险病变中可能预期的情况相反，在各诊断组之间未显示出显著差异。此外，与正常黏膜相比，风险组中的核质比略有下降。形状因子（形态学PE和轮廓指数）在识别“风险组”方面似乎帮助较小。基底细胞及其细胞核的大小对于具有高恶性转化风险的病变可能具有诊断价值。
