基于拓扑绝缘体 BiSe 带电极的电化学生物传感器用于 HIV-1 DNA 的检测。
Electrochemical biosensor based on topological insulator BiSe tape electrode for HIV-1 DNA detection.
机构信息
Centre for Quantum Physics, Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement (MOE), School of Physics, Beijing Institute of Technology, Beijing, 100081, China.
Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing, 314000, China.
出版信息
Mikrochim Acta. 2022 Jul 19;189(8):285. doi: 10.1007/s00604-022-05365-8.
A large-size BiSe tape electrode (BTE) was prepared by peeling off a 2 × 1 × 0.5 cm high-quality single crystal. The feasibility of using the flexible BTE as an efficient bioplatform to load Au nanoparticles and probe DNA for HIV-1 DNA electrochemical sensing was explored. Differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) show that the resultant biosensor has a wide linear range from 0.1 fM to 1 pM, a low detection limit of 50 aM, excellent selectivity, reproducibility and stability, and is superior to the pM DNA detection level of Pt-Au, graphene-AuNPs hybrid biosensors. This outstanding performance is attributed to the intrinsic surface state of BiSe topological insulator in facilitating electron transfer. Therefore, BTE electrochemical biosensor platform has great potential in the application for sensitive detection of DNA biomarkers.
通过剥离一个 2×1×0.5cm 的高质量单晶，制备了一个大型 BiSe 带电极 (BTE)。探讨了将柔性 BTE 用作高效生物平台来负载 Au 纳米粒子和探测 HIV-1 DNA 用于 HIV-1 DNA 电化学传感的可行性。差分脉冲伏安法 (DPV) 和电化学阻抗谱 (EIS) 表明，所得生物传感器具有从 0.1 fM 到 1 pM 的宽线性范围、50 aM 的低检测限、优异的选择性、重现性和稳定性，优于 Pt-Au、石墨烯-AuNPs 杂化生物传感器的 pM DNA 检测水平。这种出色的性能归因于 BiSe 拓扑绝缘体的固有表面状态，有利于电子转移。因此，BTE 电化学生物传感器平台在用于灵敏检测 DNA 生物标志物方面具有巨大的应用潜力。
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