Laboratory of Food Function and Nutrigenomics, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Tea Research Institute, Zhejiang University, Hangzhou 310058, China.
Int J Mol Sci. 2022 Jul 8;23(14):7595. doi: 10.3390/ijms23147595.
In recent years, many natural foods and herbs rich in phytochemicals have been proposed as health supplements for patients with metabolic syndrome (MetS). Theaflavins (TFs) are a polyphenol hydroxyl substance with the structure of diphenol ketone, and they have the potential to prevent and treat a wide range of MetS. However, the stability and bioavailability of TFs are poor. TFs have the marvelous ability to alleviate MetS through antiobesity and lipid-lowering (AMPK-FoxO3A-MnSOD, PPAR, AMPK, PI3K/Akt), hypoglycemic (IRS-1/Akt/GLUT4, Ca/CaMKK2-AMPK, SGLT1), and uric-acid-lowering (XO, GLUT9, OAT) effects, and the modulation of the gut microbiota (increasing beneficial gut microbiota such as and ). This paper summarizes and updates the bioavailability of TFs, and the available signaling pathways and molecular evidence on the functionalities of TFs against metabolic abnormalities in vitro and in vivo, representing a promising opportunity to prevent MetS in the future with the utilization of TFs.
近年来，许多富含植物化学物质的天然食品和草药被提议作为代谢综合征（MetS）患者的健康补充剂。茶黄素（TFs）是一种具有二酚酮结构的多酚羟基物质，具有预防和治疗多种代谢综合征的潜力。然而，TFs 的稳定性和生物利用度较差。TFs 通过抗肥胖和降血脂（AMPK-FoxO3A-MnSOD、PPAR、AMPK、PI3K/Akt）、降血糖（IRS-1/Akt/GLUT4、Ca/CaMKK2-AMPK、SGLT1）和降尿酸（XO、GLUT9、OAT）作用，以及调节肠道微生物群（增加有益的肠道微生物群，如 和 ），具有缓解 MetS 的奇妙能力。本文总结和更新了 TFs 的生物利用度，以及 TFs 在体外和体内对抗代谢异常的可用信号通路和分子证据，代表着利用 TFs 预防 MetS 的未来有希望的机会。
Zotero 插件
