Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, PMB, Kumasi, Ghana.
Global Health and Infectious Disease Research Group, Kumasi Centre for Collaborative Research in Tropical Medicine, College of Health Sciences, Kwame Nkrumah University of Science and Technology, PMB, Kumasi, Ghana.
Molecules. 2022 Jul 13;27(14):4475. doi: 10.3390/molecules27144475.
Amaryllidaceae is a significant source of bioactive phytochemicals with a strong propensity to develop new drugs. The genera , , and biosynthesize novel alkaloids and other phytochemicals with traditional and pharmacological uses. Amaryllidaceae biomolecules exhibit multiple pharmacological activities such as antioxidant, antimicrobial, and immunomodulatory effects. Traditionally, natural products from Amaryllidaceae are utilized to treat non-communicable and infectious human diseases. Galanthamine, a drug from this family, is clinically relevant in treating the neurocognitive disorder, Alzheimer's disease, which underscores the importance of the Amaryllidaceae alkaloids. Although Amaryllidaceae provide a plethora of biologically active compounds, there is tardiness in their development into clinically pliable medicines. Other genera, including and , have received little attention as potential sources of promising drug candidates. Given the reciprocal relationship of the increasing burden of human diseases and limited availability of medicinal therapies, more rapid drug discovery and development are desirable. To expedite clinically relevant drug development, we present here evidence on bioactive compounds from the genera , , and and describe their traditional and pharmacological applications.
石蒜科是生物活性植物化学物质的重要来源，具有很强的开发新药的倾向。属、、和合成新型生物碱和其他具有传统和药理学用途的植物化学物质。石蒜科生物分子具有多种药理活性，如抗氧化、抗菌和免疫调节作用。传统上，石蒜科的天然产物被用于治疗非传染性和传染性人类疾病。从该科中提取的加兰他敏是治疗神经认知障碍阿尔茨海默病的临床相关药物，这突显了石蒜科生物碱的重要性。尽管石蒜科提供了大量具有生物活性的化合物，但它们在开发成临床适用的药物方面进展缓慢。其他属，包括和，作为有前途的候选药物的潜在来源，几乎没有受到关注。鉴于人类疾病负担不断增加和药用疗法有限，更需要快速的药物发现和开发。为了加速具有临床相关性的药物开发，我们在此介绍了属、、和中生物活性化合物的证据，并描述了它们的传统和药理学应用。
