Xingjie Wu, Ying Chen, Qianqian Guo, Ling Tao, Yang Ding, Xianguang Ding, Xiangchun Shen
The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, University Town, Guian New District, Guiyang 550025, China.
High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, University Town, Guian New District, Guiyang 550025, China.
Pharmaceutics. 2022 Jun 29;14(7):1375. doi: 10.3390/pharmaceutics14071375.
Tumor phototherapies are light-mediated tumor treatment modalities, which usually refer to tumor photothermal therapy (PTT) and photodynamic therapy (PDT). Due to the outstanding spatial-temporal control over treatment through light irradiation, tumor phototherapies display extremely low side effects during treatment and are believed to be a tumor treatment method with a clinical translation potential. However, current tumor phototherapy nanoplatforms face obstacles, including light irradiation-induced skin burning, tumor hypoxia microenvironments, limited light penetration depth, et al. Therefore, one important research direction is developing a tumor phototherapy nanoplatform with multifunctionality and enhanced pharmacological effects to overcome the complexity of tumor treatment. On the other hand, cyclodextrins (CDs) are starch-originated circular oligosaccharides with negligible toxicity and have been used to form supermolecular nanostructures through a host-guest interaction between the inner cavity of CDs and functional biomolecules. In the past few years, numerous studies have focused on CD-based multifunctional tumor phototherapy nanoplatforms with an enhanced photoeffect, responsive morphological transformation, and elevated drug bioavailability. This review focuses on the preparation methods of CD-based tumor phototherapy nanoplatforms and their unique physiochemical properties for improving anti-tumor pharmacological efficacy.
肿瘤光疗法是光介导的肿瘤治疗方式，通常指肿瘤光热疗法（PTT）和光动力疗法（PDT）。由于通过光照射对治疗具有出色的时空控制，肿瘤光疗法在治疗过程中显示出极低的副作用，被认为是一种具有临床转化潜力的肿瘤治疗方法。然而，当前的肿瘤光疗纳米平台面临诸多障碍，包括光照射引起的皮肤灼伤、肿瘤缺氧微环境、光穿透深度有限等。因此，一个重要的研究方向是开发具有多功能性和增强药理作用的肿瘤光疗纳米平台，以克服肿瘤治疗的复杂性。另一方面，环糊精（CDs）是源自淀粉的环状寡糖，毒性可忽略不计，并已通过CDs内腔与功能生物分子之间的主客体相互作用用于形成超分子纳米结构。在过去几年中，众多研究聚焦于具有增强光效应、响应性形态转变和提高药物生物利用度的基于CD的多功能肿瘤光疗纳米平台。本综述重点关注基于CD的肿瘤光疗纳米平台的制备方法及其独特的物理化学性质，以提高抗肿瘤药理疗效。
