在采用五种不同方案进行疫苗接种运动后智利的新冠病毒中和抗体情况
SARS-CoV-2 Neutralizing Antibodies in Chile after a Vaccination Campaign with Five Different Schemes.
作者信息
Aguilera Ximena, Hormazábal Juan, Vial Cecilia, Cortes Lina Jimena, González Claudia, Rubilar Paola, Apablaza Mauricio, Ramírez-Santana Muriel, Icaza Gloria, Nuñez-Franz Loreto, Castillo-Laborde Carla, Ramírez-Riffo Carolina, Pérez Claudia, Quezada-Gate Rubén, Said Macarena, Vial Pablo
机构信息
Centro de Epidemiología y Políticas de Salud, Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Av. Plaza #680, San Carlos de Apoquindo, Las Condes, Santiago 7610658, Chile.
Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Av. Plaza #680, San Carlos de Apoquindo, Las Condes, Santiago 7610658, Chile.
出版信息
Vaccines (Basel). 2022 Jun 30;10(7):1051. doi: 10.3390/vaccines10071051.
Using levels of neutralizing antibodies (nAbs), we evaluate the successful Chilean SARS-CoV-2 vaccine campaign, which combines different vaccine technologies and heterologous boosters. From a population-based study performed in November 2021, we randomly selected 120 seropositive individuals, organized into six groups of positive samples (20 subjects each) according to natural infection history and the five most frequent vaccination schemes. We conclude that the booster dose, regardless of vaccine technology or natural infection, and mRNA vaccines significantly improve nAbs response.
我们使用中和抗体（nAbs）水平来评估智利成功开展的SARS-CoV-2疫苗接种活动，该活动结合了不同的疫苗技术和异源加强针。在2021年11月进行的一项基于人群的研究中，我们随机选择了120名血清阳性个体，根据自然感染史和五种最常见的疫苗接种方案将其分为六组阳性样本（每组20名受试者）。我们得出结论，无论疫苗技术或自然感染情况如何，加强针以及mRNA疫苗都能显著提高中和抗体反应。
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