成人血友病患者心血管疾病及相关危险因素的患病率：斯里兰卡一家三级护理医院诊所的横断面研究。

Prevalence of cardiovascular diseases and risk factors in adult patients with haemophilia: a cross-sectional study in a tertiary care hospital clinic in Sri Lanka.

机构信息

Haematology Unit, National Hospital of Sri Lanka, Colombo 10, Sri Lanka.

Department of Pathology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.

出版信息

BMC Cardiovasc Disord. 2022 Jul 30;22(1):343. doi: 10.1186/s12872-022-02789-1.

DOI:10.1186/s12872-022-02789-1

PMID:35907807

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9339172/

Abstract

BACKGROUND

Management of cardiovascular disease (CVD) in patients with haemophilia is extremely challenging. Therefore, knowing the prevalence of CVD and risk factors in this population is imperative.

METHODS

All consented patients ≥ 18 years of age attending the haemophilia clinic at a tertiary care centre were recruited to the study. Data were collected using a pretested, investigator administered questionnaire. Seated blood pressure, anthropometric measurements and blood samples were obtained using standard techniques. Lipid profile and fasting plasma glucose were estimated. Prevalence of risk factors for CVD was compared with those of age matched males in the general population. P values < 0.05 were considered significant.

RESULTS

Of the total 109 participants, 92 (84.4%) had haemophilia A. The median age of the study group was 36 years. Three (2.8%) had at least one cardiovascular disease. There were 10 (9.2%), 30 (27.5%), 13 (11.9%) and 4 (3.7%) participants with diabetes, hypertension, current smoking and obesity (Body Mass Index (BMI) ≥ 30 kg/m) respectively. 32 (29.4%) and 37 (33.9%) participants had waist circumference ≥ 90 cm and waist hip ratio ≥ 0.9 respectively. 38 (34.9%) had total cholesterol ≥ 200 mg/dl, 43 (39.5%) had low density lipoprotein (LDL) cholesterol ≥ 130 mg/dl, 25 (22.9%) had triglycerides (TG) ≥ 150 mg/dl and 58 (53.2%) had High density lipoprotein (HDL) cholesterol < 40 mg/dl. Diabetes was significantly associated with factor levels below 5% (p = 0.038). BMI, waist circumference and dyslipidaemia in the study were significantly higher compared to the general population.

CONCLUSION

The study signifies an increased prevalence of risk factors for CVD among patients with haemophilia and the need for preventive measures.

摘要

背景

血友病患者的心血管疾病（CVD）管理极具挑战性。因此，了解该人群中 CVD 的患病率和危险因素至关重要。

方法

本研究招募了在三级医疗中心血友病门诊就诊的所有年龄≥18 岁的同意参与的患者。使用经过预测试的调查员管理问卷收集数据。使用标准技术获得坐位血压、人体测量学测量值和血液样本。估计血脂谱和空腹血糖。将 CVD 危险因素的患病率与一般人群中年龄匹配男性的患病率进行比较。P 值<0.05 被认为具有统计学意义。

结果

在总共 109 名参与者中，92 名（84.4%）患有血友病 A。研究组的中位年龄为 36 岁。有 3 名（2.8%）至少有一种心血管疾病。有 10 名（9.2%）、30 名（27.5%）、13 名（11.9%）和 4 名（3.7%）参与者患有糖尿病、高血压、当前吸烟和肥胖症（体重指数（BMI）≥30kg/m）。32 名（29.4%）和 37 名（33.9%）参与者的腰围≥90cm 和腰臀比≥0.9。38 名（34.9%）参与者的总胆固醇≥200mg/dl，43 名（39.5%）参与者的低密度脂蛋白胆固醇（LDL）≥130mg/dl，25 名（22.9%）参与者的甘油三酯（TG）≥150mg/dl，58 名（53.2%）参与者的高密度脂蛋白胆固醇（HDL）<40mg/dl。糖尿病与低于 5%的因子水平显著相关（p=0.038）。与一般人群相比，研究中的 BMI、腰围和血脂异常显著更高。